SPECIALIZED CENTER OF RESEARCH IN OSTEOARTHRITIS

拟建的专业研究中心(SCOR) 骨关节炎(OA)利用现有的 印第安纳大学多用途关节炎研究人员 中心，他们已经专注于与办公自动化相关的问题。 这个高度互动的小组的新的相互关联的项目 描述了调查人员。该提案是从 透视骨性关节炎不仅仅是关节的失败 软骨，而是整个器官的，腹股沟关节，这是 由软骨下骨、滑膜、韧带和 神经肌肉器官，以及软骨。 提出了五个项目。其中一个人考察了一种 特异性非胶原软骨基质糖蛋白(CGMP) 作为骨性关节炎的非侵入性标志物和监测手段 病程和对治疗的反应。它的目标还包括 测定CGMP在血清和滑膜中的释放 骨关节炎中的液体是由于软骨基质完整性降低或 更改了CGMP的分解。第二个项目检查 细胞周围基质(PCM)，所有材料都通过它 进入和离开软骨细胞。因为蛋白多糖和 PCM中的IX和XI型胶原可能会因增加 骨性关节炎软骨细胞介导的蛋白水解酶活性的研究 分离的软骨细胞、软骨细胞和器官培养将 骨性关节炎和骨性关节炎中PCM的合成、降解和修复的比较 正常的软骨。第三个项目考察了 在骨性关节炎中防止关节破裂的保护性屏蔽。 有两个项目涉及滑膜：一个项目评估 滑膜炎症在促进滑膜损伤修复中的重要性 放射合并术和放射治疗对骨性关节炎软骨的影响 小剂量糖皮质激素治疗犬软骨病变的实验研究 骨关节炎。第二个是临床研究项目，涉及 滑膜炎在骨关节炎任务中作为疼痛原因的重要性 使用非类固醇抗炎药治疗是否 在缓解骨性关节炎症状方面比 只能用止痛药治疗。个别项目是 由五个核心单位支持：生物化学、生物统计学、 组织学/显微摄影、矫形外科手术和 行政部门。

This proposed Specialized Center of Research (SCOR) in osteoarthritis (OA) takes advantage of existing associations of researchers in the Indiana University Multipurpose Arthritis Center, who are already focused on problems relevant to OA. New inter-related projects by this highly interactive group of investigators are described. The proposal is developed from the perspective that OA does not represent failure merely of joint cartilage, but of an entire organ, the diarthrodial joint which is comprised of subchondral bone, synovium, ligaments and the neuromuscular apparatus, as well as cartilage. Five projects are proposed. One examines the potential of a specific non-collagenous cartilage matrix glycoprotein (CGMP) to serve as a noninvasive marker of OA and a means to monitor the course of the disease and response to treatment. It aims also to determine whether release of CGMP into serum and synovial fluid in OA is due to decreased cartilage matrix integrity or altered breakdown of CGMP. A second project examines the pericellular matrix (PCM), through which pass all materials entering and exiting the chondrocyte. Since proteoglycans and types IX and XI collagen in PCM may be degraded by increased chondrocyte-mediated protease activity in OA, studies of isolated chondrocytes, chondrones and organ cultures will compare synthesis, degradation and repair of PCM in OA and normal cartilage. A third project examines the importance of protective shielding against joint breakdown in OA. Two projects deal with the synovium: one assesses the importance of synovial inflammation in facilitating repair of cartilage in OA by examining effects of radiosynoviorthesis and low-dose corticosteroid therapy on cartilage changes in canine OA. The second is a clinical research project, which deals with the importance of synovitis as a cause of pain in OA tasks whether treatment with a nonsteroidal anti-inflammatory drug is more effective in providing symptomatic relief in OA than treatment only with an analgesic. The individual projects are supported by five core units: Biochemistry, Biostatistics, Histology/Photomicrography, Orthopedic Procedures and Administration.