Development and validation of a smart harness to study babies with developmental dysplasia of the hip

项目总结--曼能 发育性髋关节发育不良(DDH)是一种机械性疾病，影响多达10%的人口 分娩，但由于缺乏为研究和治疗提供信息的知识，可能会导致终生痛苦和 昂贵的生物力学问题和骨关节炎。改善治疗取决于了解婴儿是如何 在家中与Pavlik线束机械治疗支架互动，但目前还没有研究工具允许 这样的测量。此项目的目的是开发和验证“智能”线束，以在 关于接受DDH治疗的婴儿如何与支架相互作用的家庭研究。我们将(目标1)发展 用于测量Pavlik线束内生物力学的传感器(目标2)将传感器嵌入到Pavlik线束上 并通过体外测试进行验证，以及(目标3)通过体内人体受试者测试来验证智能线束。 这项研究中开发的智能马具将提供一种概念验证研究设备，在该设备上，我们可以 设计未来的研究和临床研究，以监测婴儿的佩戴时间、身体位置和踢脚数据 进行DDH治疗，使临床对这些可改变因素有了更透彻的了解 成功。该项目适合整个Cobre主题，专注于开发和嵌入灵活的 将传感器集成到生物医学应用的治疗设备中。制造、表征和测试 研究核心对这个项目的成功至关重要。具体地说，我将使用先进的制造 AIM开发新型柔性传感器的能力和设备1.电压力机械试验 将需要机器来验证来自AIM 2的传感器的踢球数据。将要求3D扫描仪 在目标3中开发智能线束的计算机模型，这将是未来计算所必需的 对完成的设备进行分析。

PROJECT SUMMARY – MANNEN Developmental dysplasia of the hip (DDH) is a mechanical disorder that impacts up to 10% of the population at birth, but given a lack of knowledge to inform research and treatment, can result in a lifetime of painful and costly biomechanical problems and osteoarthritis. Improving treatment depends on understanding how a baby interacts with the Pavlik harness mechanical therapy brace at home, yet no research tools exist that allow for such measurements. The purpose of this project is to develop and validate a “smart” harness to enable at home research relating to how babies being treated for DDH interact with the brace. We will (Aim 1) Develop sensors to measure biomechanics within the Pavlik harness, (Aim 2) Embed sensors onto the Pavlik harness and validate via in vitro testing, and (Aim 3) Validate the smart harness with in vivo human subjects testing. The smart harness developed in this study will provide a proof-of-concept research device on which we can design future research and clinical studies to monitor the wear time, body position, and kicking data of babies undergoing DDH treatment, resulting in a more thorough understanding of these modifiable factors on clinical success. This project fits within the overall COBRE theme by focusing on developing and embedding flexible sensors into a therapy device for biomedical applications. The Fabrication, Characterization, and Testing Research Core is critical to the success of this project. Specifically, I will use the advanced manufacturing capabilities and equipment to develop new flexible sensor types in Aim 1. The ElectroForce mechanical testing machine will be required to validate the kicking data from sensors in Aim 2. The 3D scanner will be required to develop computer models of the smart harness in Aim 3 and will be necessary for future computational analysis of the completed device.