Development and validation of a smart harness to study babies with developmental dysplasia of the hip

开发和验证用于研究患有髋关节发育不良的婴儿的智能安全带

• 批准号: 10557616
• 负责人: Erin Mannen
• 金额: $ 19.26万
• 依托单位: BOISE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-06 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10557616
• 关键词: 3-Dimensional; Agreement; Area; Avascular Necrosis of Femur Head; Biomechanics; Biometry; Birth; Caregivers; Centers of Research Excellence; Clinical; Clinical Research; Collection; Complication; Computer Analysis; Computer Models; Data; Data Collection; Data Reporting; Degenerative polyarthritis; Development; Devices; Disease; Dysplasia; Engineering; Equipment; Failure; Frequencies; Future; Goals; Hip Joint; Hip Osteoarthritis; Hip region structure; Home; Home environment; Hour; Human; Image; Industry Collaboration; Infant; Knowledge; Laboratories; Life; Manikins; Manuals; Measurement; Measures; Mechanics; Medical; Medical Device; Methods; Monitor; Motion; Movement; Operative Surgical Procedures; Outcome; Pain; Patient Self-Report; Population; Positioning Attribute; Recommendation; Research; Risk; Science; Shapes; Supination; Testing; Textiles; Time; Treatment Failure; Validation; Work; body position; cost; design; early onset; fabrication; femur head; flexibility; foot; human subject; improved; in vitro testing; in vivo; in vivo evaluation; manufacturing capabilities; pressure sensor; research study; sensor; success; tool

PROJECT SUMMARY – MANNEN Developmental dysplasia of the hip (DDH) is a mechanical disorder that impacts up to 10% of the population at birth, but given a lack of knowledge to inform research and treatment, can result in a lifetime of painful and costly biomechanical problems and osteoarthritis. Improving treatment depends on understanding how a baby interacts with the Pavlik harness mechanical therapy brace at home, yet no research tools exist that allow for such measurements. The purpose of this project is to develop and validate a “smart” harness to enable at home research relating to how babies being treated for DDH interact with the brace. We will (Aim 1) Develop sensors to measure biomechanics within the Pavlik harness, (Aim 2) Embed sensors onto the Pavlik harness and validate via in vitro testing, and (Aim 3) Validate the smart harness with in vivo human subjects testing. The smart harness developed in this study will provide a proof-of-concept research device on which we can design future research and clinical studies to monitor the wear time, body position, and kicking data of babies undergoing DDH treatment, resulting in a more thorough understanding of these modifiable factors on clinical success. This project fits within the overall COBRE theme by focusing on developing and embedding flexible sensors into a therapy device for biomedical applications. The Fabrication, Characterization, and Testing Research Core is critical to the success of this project. Specifically, I will use the advanced manufacturing capabilities and equipment to develop new flexible sensor types in Aim 1. The ElectroForce mechanical testing machine will be required to validate the kicking data from sensors in Aim 2. The 3D scanner will be required to develop computer models of the smart harness in Aim 3 and will be necessary for future computational analysis of the completed device.

项目概要-曼恩 发育性髋关节发育不良（DDH）是一种机械性疾病，影响高达10%的人口， 分娩，但由于缺乏为研究和治疗提供信息的知识，可能会导致一生的痛苦和痛苦 昂贵的生物力学问题和骨关节炎。改善治疗取决于了解婴儿 在家里与帕弗里克挽具机械治疗支具相互作用，但没有研究工具存在，允许 这样的测量。该项目的目的是开发和验证一种“智能”线束， 家庭研究有关婴儿如何治疗DDH与支具相互作用。我们将（目标1）发展 用于测量Pavlik安全带内生物力学的传感器，（目标2）将传感器嵌入Pavlik安全带 并通过体外测试进行验证，以及（目标3）通过体内人类受试者测试验证智能安全带。 这项研究中开发的智能线束将提供一个概念验证研究设备，我们可以 设计未来的研究和临床研究，以监测婴儿的穿戴时间、身体位置和踢腿数据 接受DDH治疗，从而更彻底地了解这些可改变的因素对临床 成功该项目符合整个COBRE主题，重点是开发和嵌入灵活的 将传感器转化为用于生物医学应用的治疗设备。制造、表征和测试 研究核心对这个项目的成功至关重要。具体来说，我会用先进的制造业 在Aim 1中开发新型灵活传感器的能力和设备。ElectroForce机械测试 将需要一台机器来验证目标2中传感器的踢出数据。3D扫描仪必须 在目标3中开发智能线束的计算机模型，并将用于未来的计算 完成的设备的分析。