THE PROTECTIVITY OF AN ANTI-SUBTYPE ANTIBODY AGAINST HBV INFECTION

B型肝炎表面抗原（HBsAg）由组特异性 决定簇a和至少两个亚型系统d/y和w/r。d/y和 W/R特异性以等位基因的方式表现，它们代表了 HBV不同基因型的表达。 因此，针对HBV感染的保护作用归因于 针对共同组决定簇的抗体，a. 尚未评估抗亚型抗体的保护性。的 对决定簇d的单克隆抗体的可用性进行了评价 可能一只黑猩猩被静脉注射了标准的乙肝病毒 接种物（adw亚型，10，000 CID-50），其已经用 225-倍过量的单克隆抗-D。接种后 一只黑猩猩没有表达任何HBV感染的血清学标志物， 为期44周。在这一时期结束时，黑猩猩 用标准接种物挑战，发现其敏感。因此，我们认为， 通过该单克隆抗-D实现中和。

The hepatitis B surface antigen (HBsAg) consists of a group-specific determinant, a, and at least two subtype systems, d/y and w/r. The d/y and w/r specificities behave in an allelic manner and they represent the expression of distinct genotypes of HBV. Heretofore, protection against HBV infection has been ascribed to antibodies directed toward the common group determinant, a. Protectivity by the anti-subtype antibodies has not been assessed. The availability of monoclonal antibody to determinant, d, made this evaluation possible. A chimpanzee was intravenously inoculated with the standard HBV inoculum (adw subtype, 10,000 CID-50) which had been preincubated with 225-fold excess of the monoclonal anti-d. After the inoculation, the chimpanzee did not express any serological markers for HBV infection for a period of 44 weeks. At the end of that period, the chimpanzee was challenged with the standard inoculum and found to be susceptible. Hence, neutralization was achieved by this monoclonal anti-d.