RESOURCE FOR BIOMEDICAL COMPUTING

要求为生物技术资源提供持续支助， 为华盛顿大学医学院和国家 通过合作研究建立社区。该计划推进了生物医学 通过将最先进的计算技术带到 生物医学环境。研究活动包含理论 发展、基本数字设计、生物信号处理和 面向生物医学研究的概念性信息系统开发 应用，以及商业和商业中完整系统的现场部署 全国范围内的大学环境。发展数字化的具体目标 计算技术包括算法和计算机系统开发 针对心电信号的高速分析，研究了广义信源编码 对于数据压缩，层析图像的算法开发 重建，开发探测器性能评估模型， 结合VLSI的分布式多处理器系统的实现 数据库机器的设计和设计研究。具体目标为 与生物医学科学家的合作跨越了基础科学领域 临床医学。建议的项目包括实施和研究 用于疾病管理和研究、设计和开发的医学数据库 正电子发射横轴断层扫描系统的构建 光子飞行时间测量，实现了一种新的三维测量方法 辐射剂量估算，使用专门的硬件、颜色 使用计算机控制的视频显示器绘制视野图， 神经解剖放射自显影的分析，系统的开发 用于DNA限制图谱的自动凝胶电泳仪读数，以及 采用高速心电分析的多项地方和国家研究。 具体目标是为用户提供灵活的即席服务 安排；用于培训科学家进行生物医学计算的安排 强调短期课程和研讨会；传播的目标包括 出版、演示和导出算法、设备和 完整的系统。

Continuation support is requested for a biotechnology resource which serves the Washington University School of Medicine and the national community through collaborative research. The program advances biomedical research by bringing state-of-the-art computing techniques to the biomedical environment. Research activities embrace theoretical developments, basic digital designs, processing of biological signals and conceptual information system developments for biomedical research applications, and the fielding of complete systems in the commercial and university environments nationally. Specific aims to develop digital computing technologies include algorithm and computer system developments for high-speed analysis of ECGs, research on generalized source encoding for data compression, algorithm developments for tomographic image reconstruction, development of a detector-performance evaluation model, implementation of distributed multiprocessor systems incorporating VLSI designs, and design studies of database mechines. Specific aims for collaborations with biomedical scientists span basic sciences through clinical medicine. Proposed projects include the implementation and study of medical databases for disease management and research, design and construction of a positron-emission transaxial tomography system employing photon time-of-flight measurements, implementation of a new method for 3-D radiation dose estimation which employs specialized hardware, color mapping of visual fields using computer controlled video displays, analysis of neuroanatomical autoradiographs, development of a system for automated electrophoretic gel reading for DNA restriction mapping, and multiple local and national studies employing high-speed ECG analysis. Specific aims for offering services to users provide flexible ad hoc arrangements; those for training scientists in biomedical computing emphasize short courses and seminars; and aims for dissemination include publications, presentations and export of algorithms, devices, and complete systems.