ROLE OF CNS ADAPTIVE MECHANISMS IN OROFACIAL SENSATION

该项目的目标是(I)确定和描述 动态中枢神经系统适应机制 控制大脑皮层对躯体刺激的反应 正常受试者，以及(Ii)确定他们对 已知与以下情况相关的操作和条件 人类的口面部感觉障碍。一组调查人员 在体感神经生理学方面有丰富的经验， 药理学，人类和动物心理物理学，以及计算机- 辅助神经生物学研究联合起来研究(I) 躯体感觉神经系统信息加工的变化 与试验性修改相关(长期和短期) 感觉输入与人类所经历的一致 无论是在日常生活中还是在随后的 创伤性损伤或疾病；(二)躯体感觉变化 伴随人类临床疼痛的信息处理；以及 (3)正常人和患者的行为能力 评价口腔面部感觉障碍患者的皮肤运动 皮肤。预计这一基础和临床计划 研究将：(I)促进以下方面的互动和合作 具有不同背景的调查人员；(2)支持核心 旨在促进多学科研究的设施 体感；以及(Iii)刺激思想交流， 仪器、技术诀窍和实验材料。

The aims of the project are (i) to identify and characterize the dynamic central nervous system adaptative mechanisms which govern the cerebral cortical response to somatic stimulation in normal subjects, and (ii) to determine their susceptability to manipulations and conditions known to be associated with orofacial sensory disorders in man. A team of investigators having extensive experience in somatosensory neurophysiology, pharmacology, human and animal psychophysics, and computer- aided neurobiological research have joined forces to study (i) the changes in somatosensory nervous system information processing associated with experimental modifications (long- and short-term) of sensory input consistent with those experienced by human subjects either in the course of everyday life or subsequent to traumatic injury or disease; (ii) the changes on somatosensory information processing accompanying clinical pain in man; and (iii) the capacity of normal human subjects and patients with orofacial sensory disorders to evaluate cutaneous motion on the skin. It is anticipated that this program of basic and clinical research will: (i) promote interactions and collaborations between investigators with different backgrounds; (ii) support core facilities designed to facilitate multidisciplinary research on somesthesia; and (iii) stimulate the exchange of ideas, instrumentation, know-how, and experimental materials.