BIOLOGICAL AND BIOCHEMICAL STUDIES OF ANTIGENS ON MALARIA-INFECTED RED CELLS

我们正在研究疟疾蛋白的结构和功能。 插入并穿过感染的红细胞膜 内皮细胞上有成熟的无性寄生虫和分子 参与细胞黏附的细胞。 分子生物学方法正在被开发用于尝试 诺氏疟原虫感染红细胞变异型抗原的克隆 和我们早期研究的恶性疟原虫蛋白PfEMP1 与这些细胞的细胞黏附特性有关。

We are studying the structure and function of malarial proteins inserted into and through the membrane of erythrocytes infected with mature asexual parasites and molecules on the endothelial cells involved in cytoadherence. Molecular biological approaches are being developed for attempted cloning of the P. knowlesi variant antigen on infected erythrocytes and the P. falciparum protein PfEMP1 that our earlier studies implicated in the cytoadherence property of these cells.