PHOTODYNAMIC THERAPY: BASIC SCIENCE STUDIES

这项提议的总体目标是发展一种更好的 对其基本作用机制的认识 光动力疗法(PDT)。该计划是对 韦恩州立大学亨利·福特医院的研究活动 大学和奥克兰大学以及直接延伸的 在光动力疗法领域正在进行的其他研究合作。这个 该项目由两个核心和四个单独的提案组成。这个 核心是支持整体管理职能和 为所有四个项目提供生物统计学支持。 项目1建议调查 光动力疗法对宠物动物原发肿瘤的治疗效果。项目 2计划研究将PDT与 另一种新的治疗方式，热疗，已经在 至少有一个生理反应机制与 光动力疗法。正常组织对光动力疗法的反应，特别是大脑，将是 在项目3中进行了研究。最后，项目4建议比较PDT 使用常规照明通过以下方式照明 化学发光。最终，这些研究将提供一种 更好地了解涉及的基本机制 光动力疗法。

The overall objective of this proposal is to develop a better understanding of the basic mechanisms of action of Photodynamic Therapy (PDT). The program is an integration of research activities at Henry Ford Hospital, Wayne State University and Oakland University and a direct extension of other ongoing research collaborations in the area of PDT. The project consists of two cores and four separate proposals. The cores are to support overall administrative functions and for biostatistical support of all four projects. Project 1 proposes to investigate parameters for the effectiveness of PDT in primary tumors in pet animals. Project 2 plans to investigate the possibility of combining PDT with another new treatment modality, hyperthermia, which has at least one physiological response mechanism in common with PDT. Normal tissue response to PDT, in particular brain, will be studied in Project 3. Finally, Project 4 proposes to compare PDT with conventional illumination to illumination by chemiluminescence. Ultimately, these studies will provide a better understanding of the underlying mechanisms involved in PDT.