ALCOHOL ABUSE AND REGIONAL CEREBRAL FUNCTION

这项研究的目标是定义一些生理和 由于酗酒而在大脑中发生的病变。老鼠会 用于实验模型研究急性和慢性的影响 酒精中毒。 酒精是否会选择性地影响特定的大脑结构 从来没有得到全面的解决。在人类身上的大多数观察 被随之而来的营养缺乏所困扰。目前还不清楚 无论是酒精还是营养不良，还是两者的组合，这 是与以下疾病相关的公认的大脑异常的原因 长期饮酒。体内作用部位的确定是 对进一步了解酒精的影响至关重要 为今后的实验设计提供了依据。 因此，以下内容将在严格控制的研究中进行测量 它们特别注重营养。 大脑局部葡萄糖代谢将被用作神经的一种衡量标准 个体大脑结构的功能。这将使用以下方法进行测量 [6-14C]-葡萄糖作为示踪分子。 血脑屏障对四种基本营养素的渗透性， 将测定葡萄糖、苯丙氨酸、赖氨酸和3-羟基丁酸酯。 这些都是重要的运输系统的代表，它们协调着 供需之间微妙的平衡。扰乱了这种平衡， 这很可能发生在酗酒之后，可能会有重要的 对大脑功能的影响。

The goal of this research is to define some of the physiological and pathological changes that occur in brain due to alcohol abuse. Rats will be used in an experimental model to study the effect of acute and chronic alcohol intoxication. The question whether alcohol selectively affects specific brain structures has never been comprehensively addressed. Most of the observations in man are confused by concomitant nutritional deficiencies. It is not clear whether it is alcohol or malnutrition, or a combination of the two, which is responsible for the well established brain abnormalities associated with chronic alcohol use. The determination of the site of action in vivo is of vital importance to the further understanding of the effect of alcohol as well as providing the basis for the design of future experiments. Therefore, the following will be measured in carefully controlled studies which pay particular attention to nutrition. Regional cerebral metabolism of glucose will be used as a measure of neural function of individual cerebral structures. This will be measured using [6-14C]-glucose as a tracer molecule. Permeability of the blood-brain barrier to four essential nutrients, glucose, phenylalanine, lysine and 3-hydroxybutyrate, will be determined. These are representatives of important transport systems which mediate a delicate balance between supply and need. Disturbances of this balance, which may well occur following alcohol abuse, can have important consequences for cerebral function.