DECUBITUS ULCERS AND CACHEXIA--DIET AND CELL BIOLOGY

本研究主要从两个方面展开。一种是临床饮食 压疮愈合的干预研究。第二个是一个 儿童精神分裂症发生发展的生物学变量研究 压疮和恶病质。该项目旨在测试 假说认为恶病质患者的特点是低瘦 体重、贫血、低蛋白血症和/或低胆固醇血症 因低水平而损害细胞生长和新陈代谢 循环脂蛋白，低水平的细胞生长因子， 或抑制因子水平升高。使用的体外系统 用~3H-胸腺嘧啶核苷测定成纤维细胞的增殖 被掺入DNA中，正被用于检测血浆和血清 来自老年受试者--促进或抑制生长 物质。这个项目可能会让我们深入了解这些机制 减轻体重，促进卧位症的发生 老年人的皮肤溃疡。

There are two aspects of this study. One is a clinical dietary intervention study on the healing of decubiti. The second is a study of biological variables underlying the development of decubiti and cachexia. The project is designed to test the hypothesis that patients with cachexia, characterized by low lean body mass, anemia, hypoalbuminemia and/or hypocholesterolemia have impaired cell growth and metabolism because of low levels of circulating lipoproteins, low levels of a cellular growth factor, or elevated levels of an inhibitory factor. In vitro systems using fibroblast cell proliferation, measured by 3H-thymidine incorporation into DNA, is being used to assay plasma and sera from elderly subjects for growth-stimulatory or inhibitory substances. This project may give insight into the mechanisms causing weight loss and promoting the occurrence of decubitus skin ulcers in the elderly.