LAMININ RECEPTOR AND ITS ROLE IN THE FUNCTION OF NATURAL KILLER CELLS

自然杀伤(NK)细胞，大颗粒细胞的一个亚群 淋巴细胞(LGL)参与肿瘤的自发溶解 或被病毒感染的目标细胞。杀戮行动需要 杀伤细胞与靶细胞的结合。美国政府的角色 层粘连蛋白受体在这一特定结合过程中 在我们的实验室里进行了检验。利用小鼠NK细胞， 层粘连蛋白样分子和层粘连蛋白结合受体 已建立(10-11万KD，约99,000 受体/细胞)。 进一步的研究将尝试定义和比较受体 NK细胞与已建立的层粘连蛋白受体定位 在许多肿瘤细胞上；这两个受体之间的相互作用 在细胞裂解过程中将进行探索。

Natural killer (NK) cells, a subpopulation of large granular lymphocytes (LGL) are involved in the spontaneous lysing of tumor or virally infected target cells. The killing action requires binding of the killer cells to the target cells. The role of the laminin receptor in this process of specific binding is being examined in our laboratories. Using murine NK cells, the presence of laminin-like molecule and a receptor for laminin binding has been established (Kd 10-11 M, approximately 990,000 receptors/cell). Further studies will attempt to define and compare the receptor on NK cells versus the already established laminin receptor located on many tumor cells; the interactions between these two receptors during cell lysis will be explored.