COMPUTER SYSTEMS AND APPLICATIONS FOR NUCLEAR MEDICINE

LAS开发基于计算机的数学分析、模式 用于支持诊断活动的识别和图像处理 临床中心核医学部与协作组 研究所。许多应用程序针对的是 与结构有关的功能，例如：从结构估计心功能 放射性核素脑室造影与正电子发射计算机断层扫描(功能数据)的比较 核磁共振或CT扫描(解剖学数据)。主要的应用程序是 在心脏图像数据的分析、配准和分割中。 已开发出一套用于三维测量的自动化系统。 重复记录受试者的心脏PET发射数据 不使用基准点或等高线的研究。系统正在被 为创建体积投影序列而开发 数据，投影与层析数据的对准和应用 平移和旋转体积的感兴趣二维区域 数据。其他问题涉及将体积数据投影到 以有意义和有用的方式显示二维CRT屏幕 研究人员和如何最好地可视化体积PET的问题 叠加在MRI或CT卷上，具有不同级别的 透明度。该项目使用的计算机平台包括VAX、 Macintosh、与IBM兼容的PC和Unix工作站。 LAS，与世界卫生组织核医学部合作 在过去的六年里，临床中心设计并指定了一种 通用图像处理系统幻影。编程是 由LAS和核医学监督的承包商执行 部门。完成的基本系统已经移植到几个 其他NIH计算机系统，包括VAX工作站和Macintosh 系统。北方许多学术和商业机构 美国和欧洲已经要求并收到了该系统的副本。 基于Unix的下一代系统的工作已经开始 工作站。该系统将整合幻影的功能 具有先进的3D可视化、分析和配准功能。

LAS develops systems for computer-based mathematical analysis, pattern recognition and image processing in support of diagnostic activities in the Nuclear Medicine Department of the Clinical Center and collaborating Institutes. Many applications are directed toward the correlation of function with structure, such as: estimation of ventricular function from radionuclide ventriculography or PET scan (functional data) compared to MRI or CT scans (anatomical data). The primary application has been in the analysis, registration, and segmentation of cardiac image data. An automated system has been developed for three-dimensional registration of cardiac PET emission data for a subject over repeated studies without use of fiducial points or contours. Systems are being developed for the creation of sequences of projections of volumetric data, alignment of projection to tomographic data and for application of two-dimensional regions-of-interest to translated and rotated volumetric data. Other problems involve projection of volumetric data to a two-dimensional CRT screen in ways that are meaningful and useful to researchers and the problem of how best to visualize volumetric PET superimposed on an MRI or CT volume with variable levels of transparency. Computer platforms used in this project include the Vax, Macintosh, IBM-compatible PC, and UNIX workstations. LAS, in collaboration with the Nuclear Medicine Department of the Clinical Center has, over the past six years, designed and specified a general-purpose image processing system, MIRAGe. Programming was performed by contractors supervised by LAS and the Nuclear Medicine Department. The completed basic system has been ported to several other NIH computer systems including Vax workstations and Macintosh systems. Many academic and commercial institutions across North America and Europe have requested and received copies of the system. Work has begun on the next generation system based on a UNIX workstation. This system will incorporate the functionality of MIRAGe with advanced 3D visualization, analysis and registration capabilities.