ROLE OF MONOCYTES IN AIDS AND AS TARGETS FOR ANTIVIRAL THERAPY

大脑中的炎症过程需要 免疫活性细胞和神经胶质细胞，它们通过分泌 双向介质 神经系统内的常驻细胞可以 合成和分泌炎性细胞因子以及神经肽， 促进CNS内对损伤或免疫反应 挑战. 虽然细胞活化和免疫的机制 相互作用知之甚少，积累的证据表明， 这些通路在神经发病机制中的作用。 例如，在收购 免疫缺陷综合征（艾滋病），HIV-1诱导的神经系统 功能障碍和痴呆症与存在 浸润性白细胞和炎性细胞因子的释放 包括转化生长因子β。 定义以下途径 细胞因子失调和神经毒性引起的浸润 白细胞，以及神经细胞本身的贡献， 可能有助于确定这方面和其他方面的干预机制 使人衰弱的CNS疾病。

Inflammatory processes in the brain require the cooperation of immunocompetent cells and glial cells, which communicate by secreting bidirectional mediators. Resident cells within the nervous system can synthesize and secrete inflammatory cytokines, as well as neuropeptides, contributing to the response within the CNS to injury or immunological challenge. Although the mechanisms of cell activation and immune interaction are poorly understood, accumulating evidence implicates these pathways in neuropathogenesis. For example, in the acquired immunodeficiency syndrome (AIDS), HIV-1-induced nervous system dysfunction and dementia are associated with the presence of infiltrating leukocytes and the release of inflammatory cytokines including transforming growth factor beta. Defining the pathways of cytokine dysregulation and neurotoxicity invoked by the infiltrating leukocytes, as well as the contribution of the neural cells themselves, may help to identify mechanisms of intervention in this and other debilitating CNS diseases.