NEUROPHYSIOLOGY & NEUROPSYCHOLOGY IN MENTAL RETARDATION

这是一份计划项目补助金的续期申请， 阐明完整和实验性发展的重要方面 受损的哺乳动物基底神经节和大脑皮层研究如下 两个主题：第一个是神经元通讯的发展， 皮层和基底神经节的条件学习。第二个主题 关注产前和早期妊娠对神经元通讯的影响， 产后脑损伤该赠款的五个组成项目中的每一个 至少涉及其中一个主题， 假设 该研究涉及基础电生理学、药理学和 体外（脑切片）和体内发育神经元的形态学研究 vivo.重要的行为研究将评估功能恢复后， 产前皮质病变，并将检查的细胞基础， 条件学习许多将要进行的实验都是为了 作为大脑发育障碍的模型，包括精神障碍， 迟钝一些基本方法已经被应用于 未成熟人脑组织在小儿癫痫临床项目中应用 （单独供资）。最后，该计划项目赠款作为一个 研究生和博士后的重要培训工具， 精神发育迟滞研究中心。

This is a renewal application for a program project grant designed to elucidate important aspects of development in intact and experimentally damaged mammalian basal ganglia and cerebral cortex. The research follows two main themes: The first is development of neuronal communication and conditioned learning in the cortex and basal ganglia. The second theme concerns the effects on neuronal communication of prenatal and early postnatal brain damage. Each of the five component projects of this grant is addressed to at least one of these themes and to their underlying hypotheses. The research involves basic electrophysiological, pharmacological, and morphological studies of developing neurons in vitro (brain slices) and in vivo. Important behavioral studies will assess recovery of function after prenatal cortical lesions, and will examine the cellular bases of conditioned learning. Many of the experiments to be undertaken are designed as models for developmental brain disabilities, including mental retardation. Some of the basic approaches are already being applied to immature human brain tissue in a clinical program on pediatric epilepsy (separately funded). Finally, this program project grant acts as an important training vehicle for graduate and postdoctoral students in the Mental Retardation Research Center.