PATERNALLY-MEDIATED EFFECTS ON REPRODUCTION

从历史上看，影响遗传和环境因素的研究 后代的繁殖和随后的发展一直是中心 在女性身上。直到最近，我们才开始意识到 男性可能扮演的角色的复杂性。在动物身上，有 大量实验证据表明，治疗 雄性携带毒物，然后与未经治疗的雌性交配，可能会导致 各种不利的生殖后果。这些不利影响对 后代不一定是通过通常的雄性测试来预测的 生殖功能，因为这些可能是正常的，而后代 畸形或死亡。 只有少数几项研究解决了父系介导的不利影响 人类的生殖结果。这些典型的标志是不充分的 数据、狭隘的曝光范围和方法问题。本年度内 我们调查了世界文学，包括动物和人类，以确定 进行更广泛和更严格的 研究男性在人类中的生殖结果。这为我们提供了 对即将进行的文献的全面回顾和综合 已提交以供出版；受邀介绍调查结果 在第一次致力于男性中介的专业会议上 生殖影响。 基于这项工作，有必要对男性介导性肺炎进行流行病学研究 生育结果是明确的。我们搜索了一个合适的数据集 这将是这样一项研究的基础，并在 英国布里斯托尔大学。我们已经确定了设计和范围 这次调查和移动是为了保护将可用的数据 早在1993年初。关于职业和环境危害的工作 分类工作正在进行中，分析工作将在 数据磁带是安全的。

Historically, research on genetic and environmental factors affecting reproduction and subsequent development of the offspring has been centered on the female. Only recently have we come to appreciate the extent and complexity of the role that the male may play. In animals, there is substantial body of experimental evidence indicating that treatment of males with toxicant, followed by mating to untreated females, can result in a variety of adverse reproductive outcomes. These adverse effects on offspring cannot necessarily be predicted by the usual tests of male reproductive function, for these may be normal while the offspring are malformed or die. Only a handful of studies have addressed paternally mediated adverse reproductive outcomes in humans. These are typically marked by inadequate data, narrow exposure focus, and methodologic problems. During this year we have surveyed the world literature, both animal and human, to determine the advisability and feasibility of conducting a broader and more rigorous study of male-mediated reproductive outcomes in humans. This has provided a comprehensive review and synthesis of the literature that is about to be submitted for publication; an invited presentation of the findings was given at the first professional meeting to be devoted to male-mediated reproductive effects. Based on this work, the need for an epidemiologic study of male-mediated reproductive outcomes was clear. We searched for an appropriate data set that would serve at the basis for such a study, and found it at the University of Bristol, England. We have determined the design and scope of this investigation and moved to secure the data that will be available early in 1993. Work on occupational and environmental hazard classifications is proceeding, and analysis will be underway as soon as the data tapes are secured.