COMPARISON OF PLAQUE COMPOSITION IN SAPHENOUS VEINS AND CORONARY ARTERIES

本研究定量描述了动脉粥样硬化的成分， 用于冠状动脉搭桥术的隐静脉移植物中的斑块， 将这些发现与自体冠状动脉中的斑块进行了比较， 在同一个人身上。 共607个5 mm的隐静脉段， 797个5 mm的自体冠状动脉段通过 19名男性，年龄39 - 82岁（平均 61例），搭桥手术后存活1年以上。 比较 隐静脉斑块成分的平均百分比 移植物与自体冠状动脉的移植物一起放置14至26个月 动脉显示显著差异：细胞纤维组织，86% 与7%;致密纤维组织，13%与82%; p =小于0.05。 作为 旁路手术后生存时间增加， 隐静脉中的斑块发生了变化， 月的细胞和致密纤维组织的数量， 隐静脉移植物和自体冠状动脉相似：10% vs 16%和75%对71%; ns. 因此，在冠状动脉搭桥术后约7年， 大隐静脉移植物斑块的成分相似 与同一患者的自体冠状动脉中的相同。

This study describes quantitatively the components of atherosclerotic plaques in saphenous vein grafts used for aortocoronary bypass and compares the findings with the plaques in the native coronary arteries in the same men. A total of 607 five-mm segments of saphenous veins and 797 five-mm segments of native coronary arteries were examined by computerized planimetric technique in 19 men, aged 39 to 82 years (mean 61), who had survived bypass operation for more than 1 year. Comparison of the mean percentages of the plaque components in saphenous vein grafts in place for 14 to 26 months with those of the native coronary arteries revealed significant differences: cellular fibrous tissue, 86% vs 7%; dense fibrous tissue, 13% vs 82%; p = less than 0.05. As survival time after the bypass operation increased, composition of the plaques in the saphenous veins changed such that by approximately 80 months the amounts of cellular and dense fibrous tissue in both saphenous vein grafts and native coronary arterie were similar: 10% vs 16%, and 75% vs 71%; ns. Thus, by about 7 years after a coronary bypass operation the composition of plaques in saphenous vein grafts is similar to that in the native coronary arteries of the same patients.