NEUROHUMORAL CONTROL OF LUNGS AND AIRWAYS

我们建议对神经和神经体液调节进行多学科研究。 肺和呼吸道，利用细胞生物学、超微结构、生理学、 药理学、免疫学和临床研究。动物研究将会 检查心肺神经和颈动脉小体的感觉和运动通路， 它们的中枢延髓连接传出神经，反射器官反应 (呼吸、呼吸道分泌物、支气管运动张力的控制)和细胞 反应(调节平滑肌、肥大细胞、粘液腺、离子转运 和环状AMP和GMP)。Basbaum博士(D-1)将利用形态学技术 与桑普森博士合作，研究呼吸道的感觉神经和运动神经 (d-2)，谁也将对这些结构进行神经生理学研究 作为对分离的平滑肌细胞的研究。纳德尔博士(D-3)将研究影响 呼吸道上皮损伤对呼吸道和呼吸自主神经的影响。 Coleridge博士和Coleridge博士(D-4)将对 心肺感觉神经。麦克唐纳博士和米切尔博士(D-5)将利用 用形态和神经生理学技术研究颈动脉体部调节和 来定位它的中心连接。戈尔德博士(D-6)将研究相互作用 实验性变态反应中肥大细胞、介质和神经之间的关系。 Nadel，Davis和Widdicombe博士(D-7)将研究自主调节 呼吸道粘液分泌和离子传输。 临床研究将致力于将人类的动物研究与健康联系起来 和疾病，并制定专门和敏感的测试，以早期检测 疾病。布希博士(E-1)将研究夸张背后的机制 对吸入剂的支气管反应。戈尔德博士(E-2)将与 为早期发现疾病而开发的解剖学生理学测试 学习。

We propose a multidisciplinary study of neural and neurohumoral regulation of lungs and airways, using techniques of cell biology, ultrastructure, physiology, pharmacology, immunology, and clinical investigation. Animal studies will examine sensory and motor pathways of cardiopulmonary nerves and carotid bodies, their central medullary connections efferent nerves, reflex organ responses (control of breathing, airway secretions, bronchomotor tone), and cellular responses (regulation of smooth muscle, mast cells, mucus glands, ion transport and cyclic AMP and GMP). Dr. Basbaum (D-1) will utilize morphologic techniques to study sensory and motor nerves in airways, collaborating with Dr. Sampson (D-2), who will perform neurophysiological studies of these structures, as well as studies on isolated smooth muscle cells. Dr. Nadel (D-3) will study effects of airway epithelial damage on the autonomic control of airways and breathing. Drs. Coleridge and Coleridge (D-4) will perform neurophysiologic studies on cardiopulmonary sensory nerves. Drs. McDonald and Mitchell (D-5) will utilize morphologic and neurophysiologic techniques to study carotid body regulation and to locate its central connections. Dr. Gold (D-6) will study interactions betweeen mast cells, mediators and nerves in experimental canine anaphylaxis. Drs. Nadel, Davis, and Widdicombe (D-7) will examine autonomic regulation of mucus secretion and ion transport in airways. Clinical investigation will aim to relate the animal studies in humans in health and disease, and to develop specific and sensitive tests for early detection of disease. Dr. Boushey (E-1) will study mechanisms underlying exaggerated bronchial responses to inhaled agents. Dr. Gold (E-2) will correlate physiologic tests developed for early detection of disease with anatomic studies.