NEURAL INJURY AND BLOOD FLOW ALTERATION AFTER CNS TRAUMA

该中心将研究星形胶质细胞作为血管紧张素转换酶的介体的潜在作用。 脑损伤后早期的细胞外环境。这个 中心还将开发脑血管临床指标 病理生理学，这将是有用的治疗评估。另外， 我们将尝试证明因果关系 星形胶质细胞功能的特定方面与脑血流之间的关系 损伤后的调节异常。项目有：1)《发布 来自星形胶质细胞的细胞毒素和血管活性物质。 阻断阴离子转运抑制血管肿胀的假说 星形胶质细胞和/或从星形胶质细胞释放兴奋性毒素。一秒钟 假说将检验乙醇对星形胶质细胞的影响。三分之一 假说将涉及星形胶质细胞释放腺苷、H+和K+。2) “负离子通道抑制的损伤和保护机制。”这 该项目将测试关于阴离子通过 经络抑制从组织病理学角度减轻脑损伤 技巧。第二个假设将涉及酒精水平的影响。 关于颅脑损伤后的呼吸控制。3)“脑功能评估” 持续颈静脉血氧饱和度测定“：这些临床研究 将尝试验证量化程度的新技术 暂时性和区域性的代谢和血流异常 伤势严重的病人。我们将确定动静脉氧 饱和度差值可以用来连续估计大脑 氧合状态。目标是建立可用作 用于治疗评估的端点。核心将由一个 行政办公室(核心单位A)和一个数据中心和统计 计算机设施(核心单元B)。总体目标是建立手段 开展颅脑损伤患者的临床研究和发展 并在体外和体内测试关于 二次伤害发生的机制。

This center will study the potential role of astrocytes as mediators of extracellular environment in the early stages following brain injury. The center will also develop clinical indices of cerebrovascular pathophysiology which will be useful in the valuation of therapies. Also, an attempt will be made to demonstrate a cause and effect relationship between specific aspects of astroglial function and cerebral blood flow regulation abnormalities following injury. Projects are: 1) "Release of cytotoxins and vasoactive agents from astrocytes." This project will test the hypothesis that blockage of anion transport inhibits swelling of astrocytes and/or release of excitotoxins from astrocytes. A second hypothesis will examine the effect of ethanol on astrocytes. A third hypothesis will involve adenosine, H+, and K+ release from astrocytes. 2) "Mechanisms of injury and protection by anion channel inhibition." This project will test hypothesis concerning the mechanisms whereby anion channel inhibition ameliorates brain injury by histopathological techniques. A second hypothesis will concern the effects of ethanol levels on respiratory control after head injury. 3) "Assessment of brain oxygenation by continuous jugular venous oximetry". These clinical studies will attempt to verify new techniques for quantifying the extent of metabolism and blood flow malregulation both temporally and regionally in severely injured patients. We will determine if arterial-venous oxygen saturation differences can be used to continuously estimate cerebral oxygenation status. A goal is to establish parameters that can be used as endpoints for therapy assessment. The core will consist of an administrative office (Core Unit A), and a data center and statistical computer facility (Core Unit B). Overall goals are to establish the means for conducting clinical research on head injured patients and to develop and test specific hypotheses both in vitro and in vivo regarding the mechanisms whereby secondary injury occurs.