NEUROLOGIC COMPLICATIONS OF HIV

该计划项目由四个独立的研究组成 旨在以高度集成、多学科的方式探索 时尚，某些基本问题，关于临床和 人类免疫缺陷病毒(HIV)相关基础科学 神经系统疾病。重点研究是纵向研究 无症状、HIV血清阳性的个人和性别、年龄和艾滋病 与神经病学发展相匹配的风险组对照 疾病利用多个参数进行评估。在这些人中 将解决的问题是 神经系统疾病的发展与艾滋病毒感染有关， 这些疾病的自然历史，以及对 他们发展的预测因素。详细的临床和实验室 脑脊液(CSF)研究对象的评价 分析将使我们能够探索与艾滋病毒相关的 神经疾病与艾滋病毒的存在和性质有关 对艾滋病毒的免疫反应，巨细胞病毒的存在 以及对CMV的免疫反应的性质以及CMV的存在 脑反应性抗体。

This program project is a composite of four separate studies designed to explore in a highly integrated, multidisciplinary fashion, certain fundamental issues regarding the clinical and basic science of human immunodeficiency virus (HIV)- related neurological disease. The key study is a longitudinal study of asymptomatic, HIV seropositive individuals and sex, age and AIDS risk group matched controls for the development of neurological disease utilizing multiple parameters of assessment. Among the issues that will be addressed are the frequency with which neurological disease develops in association with HIV infection, the natural history of these disorders, and the identification of predictors for their development. Detailed clinical and laboratory evaluation of the study subjects with cerebrospinal fluid (CSF) analysis will allow us to explore the relationship of HIV-related neurological disease to the presence of HIV and the nature of the immune response to HIV, the presence of cytomegalovirus (CMV) and the nature the immune response to CMV, and the presence of brain reactive antibody.