STUDIES OF OCCUPATIONAL POPULATION EXPOSED TO CARCINOGENIC AGENTS

年接触致癌病毒工人的三项队列死亡研究 牛肉和鸡肉行业正在进行，以检查工人是否 罹患癌症的风险增加。研究人群包括 来自密苏里州和芝加哥的27,000名家禽工人和24,000名控制组，以及 巴尔的摩一个切肉工人工会的28,900名工人。我们有 采集了50名前家禽工人和对照组的血液，并检测了 鸡致癌病毒抗体。已从白种人中分离出DNA 从这些样本中提取的血细胞，并将进行检测以确定是否存在 利用聚合酶链式反应技术整合病毒基因组。这些研究将 调查人类是否感染了这些病毒。离体 网状内皮组织增生症病毒对人细胞感染性的检测 即将完工。40个苯氧类除草剂喷雾器的血液，以及40个 已经从澳大利亚的个人那里收集了控制，用于 测定血清中二恶英和呋喃的水平，看看那些 使用这些除草剂会显著地暴露在这些化合物中。 一项肺癌病例对照研究资料分析 肉类行业的剩余部分)已经完成。希望能识别出 行业内曝光率过高(S)负有责任。尿液 来自新墨西哥州阿尔伯克基超市45名工人的样本 被收集并正在分析Muconic酸，一种代谢物 苯。这项研究的目的是看看极少量的 聚氯乙烯热分解过程中产生的苯 在包装肉类的过程中，可以在尿液中检测到塑料。

Three cohort mortality studies of workers exposed to oncogenic viruses in the beef and chicken industry are being conducted, to examine if workers are at increased risk of developing cancer. The study populations consist 27,000 poultry workers from Missouri and Chicago and 24,000 controls, and 28,900 workers belonging to a meatcutters union in Baltimore. We have collected blood from 50 former poultry workers and controls, and tested for antibodies to chicken oncogenic viruses. DNA has been isolated from white blood cells from these samples, and will be tested for presence of integrated viral genome using the PCR technique. These studies will investigate whether humans are infected with these viruses. In vitro testing of the infectivity of reticuloendotheliosis virus for human cells is almost completed. Blood from 40 sprayers of phenoxy herbicides, and 40 controls has been collected from individuals in Australia, for the determination of serum levels of dioxins and furans, to see if persons who use these herbicides are significantly exposed to these compounds. Analysis of data from a case-control study of lung cancer (occurring in excess) in the meat industry has been completed. It is hoped to identify the exposure(s) within the industry responsible for the excess. Urine specimens from 45 workers in supermarkets in Albuquerque, New Mexico have been collected and are being analyzed for muconic acid, a metabolite of benzene. The purpose of this study is to see if the very small amounts of benzene emitted from the thermal decomposition of polyvinyl chloride plastic during the wrapping of meat, can be detected in the urine.