ADVANCING CHILD HEALTH THROUGH CELL/MOLECULAR BIOLOGY

通过细胞/分子生物学促进儿童健康是总的主题 密歇根大学儿童健康研究中心。 的目标 UM CHRC是为了增加儿科的数量和有效性， 科学家通过跨部门的方法，这将提供一流的 由位于基础设施的成熟的细胞/分子生物学家指导 科学和临床部门以及霍华德休斯 医学研究所，广泛的核心实验室设施和 服务，以及持续的机构和部门承诺。 的 儿科系在研究和治疗方面有着悠久的传统， 儿科医生的培训。 在过去的20年里， 特别是在过去十年中，该部扩大了其 研究兴趣，活动和成就到显着的程度。 该部门决定在其强大的临床项目的基础上， 生理学，并在医学院的计划中发挥重要作用，以进一步 发展细胞临床相关领域的研究项目， 分子生物学 这一承诺背后的理由是， 相信治疗和预防大多数先天性心脏病的重大进展 儿童期获得性疾病只有在细胞和 分子病因学是已知的。 为了实现我们的目标， 征聘和/或培训了高级和初级调查员， 以科学为导向的奖学金培训指导方针和计划， 制定并遵守了广泛的部门内和部门间 合作努力得到了促进， 一直致力于允许所需的物质和人类的扩张， 资源 此外，必要的行政系统和指导 为初级教育提供额外的培训和指导 教师，以确保他们作为独立的调查人员的成功。 电流 高级研究员和初级教师的研究活动，他们都是 在既定调查人员的指导下，旨在获得 了解这些令人不安的疾病的基本原因， 儿童期癌症、遗传性和后天性精神发育迟滞和唐氏症 综合征，囊性纤维化，先天性和后天性异常， 白色和红细胞的产生或功能，分子发病机制 微生物疾病和几种形式的吸收不良。 支持 这笔赠款将大大增强该部门的能力， 提高训练有素的儿科科学家的数量和质量， 使我们能够更充分地利用 我们的中心的资源;这样做，它将有助于满足一个关键的 孩子的需要。

Advancing Child Health Through Cell/Molecular Biology is the overall theme of the University of Michigan's Child Health Research Center. The goal of the UM CHRC is to increase the number and effectiveness of pediatric scientists through an interdepartmental approach which will provide superb mentorship by well-established cell/molecular biologists located in basic science and clinical departments as well as within the Howard Hughes Medical Institute, an extensive array of core laboratory facilities and services, and ongoing institutional and departmental commitments. The Department of Pediatrics has a long tradition of excellence in research and in the training of academic pediatricians. During the last 20 years and especially during the last decade, the department expanded the scope of its research interests, activities, and accomplishments to a remarkable degree. The department decided to build upon its strong programs in clinical physiology and to play a major role in the medical school's plan to further develop research programs in clinically relevant areas of cell and molecular biology. The rationale underlying this commitment is the firm belief that major advances in the therapy and prevention of most congenital and acquired disorders of childhood will only be possible when cellular and molecular etiologies are known. To meet our objective a large cohort of senior and junior investigators have been recruited and/or trained, scientifically-oriented fellowship training guidelines and programs have been developed and adhered to, extensive intra- and interdepartmental collaborative efforts have been fostered, and significant resources have been committed to allow for the needed expansion of physical and human resources. Moreover, the necessary administrative systems and mentorship have been established to provide additional training and guidance of junior faculty to ensure their success as independent investigators. Current research activities of senior fellows and junior faculty, all of whom are under the guidance of established investigators, are aimed toward acquiring an understanding of the basic cause(s) of such troubling disorders as childhood cancer, genetic and acquired forms of mental retardation and Down syndrome, cystic fibrosis, congenital and acquired abnormalities in the production or function of white and red blood cells, molecular pathogenesis of microbial diseases, and several forms of malabsorption. Support provided by this grant will significantly amplify the department's ability to increase the number and quality of well trained pediatric scientists by allowing us to more thoroughly utilize the remarkable scientific strengths and resources of our center; and in so doing, it will help meet a crucial need of children.