SCOR IN CORONARY AND VASCULAR DISEASES

尽管对动脉粥样硬化的研究主要集中在动脉粥样硬化的机制上 启蒙，相对较少关注更紧迫的问题 血管术后疾病进展和复发的问题 重建。SCOR有两个主要目标：制定一个 对颈动脉粥样硬化斑块如何扩大和迅速扩大的认识 某点成为血栓栓塞症事件的原因；并加以探讨 修复反应和腔内复发的不同方面 动脉内膜切除术后狭窄。其中四个项目将审查 晚期颈动脉和股动脉粥样硬化的超声特征 病变和动脉内膜切除术引起的内膜增厚。这些将是 与临床症状和病理特征相关 切除的手术标本。此外，这些损伤将是 通过原位杂交和Northern分析检测其表达 对平滑肌生长很重要的特定基因。 磁共振成像研究将在体外和体内进行。 模型系统，以开发更好的方法来研究形态和 人类斑块的生化特征。同时，动物 疾病进展和复发性狭窄的模型将发展为 定义调节平滑肌增殖和内皮细胞的因子 再生。除行政核心外，SCOR还将拥有 形态学和图像分析核心提供组织学、 为个体提供免疫细胞学和图像处理支持 项目。 拟议的研究将利用广泛的临床基础知识。 研究方法，包括超声波、核磁共振、光和电子 显微镜、原位杂交、Norther分析、细胞周期分析 生长因子生物化学的动力学和现代方法。

Although research in atherosclerosis has focused on mechanisms of initiation, relatively little attention has been given to the more pressing problems of disease progression and recurrence after vascular reconstruction. There are two major objectives in the SCOR: to develop an understanding of how carotid atherosclerotic plaques enlarge and at a certain point become the cause of thromboembolic events; and to explore various aspects of the reparative response and the recurrence of lumenal narrowing after endarterectomy. Four of the projects will examine ultrasound characteristics of advanced atherosclerotic carotid and femoral lesions and endarterectomy-induced intimal thickening. These will be correlated with clinical symptoms and with the pathological characteristics of the excised surgical specimens. In addition, these lesions will be examined by in situ hybridization and Northern analysis for the expression of specific genes important for smooth muscle growth. Magnetic resonance imaging studies will be undertaken in vitro and in vivo model systems to develop better methods for the morphological and biochemical characterization of the human plaque. At the same time, animal models of disease progression and recurrent stenosis will be developed to define factors regulating smooth muscle proliferation and endothelial regeneration. In addition to an Administrative Core, the SCOR will have Morphology an Image Analysis Cores to provide histological, immunocytological, and image procession support for the individual projects. The proposed studies will make use of a wide range of clinical basic research approaches, including ultrasound, MRI, light and electron microscopy, in situ hybridization, Norther analysis, analysis of cell cycle kinetics and modern approaches to growth factor biochemistry.