ALZHEIMER'S DISEASE CENTER CORE GRANT

拟建的梅奥诊所阿尔茨海默病研究中心(ADRC)是 旨在成为一项重要的患者评估、研究和教育 中西部上段的资源。流行病学研究利用了 梅奥诊所的人口数据库提供了第一个年龄--和 在美国，痴呆症的性别发病率。 梅奥诊所ADRC将通过一项 建立城市患病率的前瞻性社区调查 和明尼苏达州奥姆斯特德县的农村人口。病例/对照研究 已被设计用于评估病因风险因素，包括家族性 聚集、环境和职业毒性暴露。在 在社区调查过程中，大量非痴呆老年人 将确定主题，并为常用的规范性值 老年人和高龄老人的神经心理测试(80和 已结束)将被建立。这个ADRC的一个独特之处是它有能力 将基于社区的人口与转诊人口进行比较 尊重人口统计和临床特征以及 生存能力。 一个神经药理学研究项目将研究毒扁豆碱乙酰胆碱 阿尔茨海默病的受体亚型。一项神经成像项目将 内侧颞叶结构的体积变化与 通过磁共振成像测量和测量的功能变化 通过神经心理学的单光子发射计算机断层扫描， 阿尔茨海默病患者的临床和人口学特征 并以纵向方式进行正常对照。 拟议中的亚洲发展研究中心在最初几年的主要重点将是 为阿尔茨海默病患者建立区域转诊中心 疾病。梅奥诊所正在扩大其对阿尔茨海默氏症的承诺 通过建立阿尔茨海默病研究机构进行疾病研究 作为其佛罗里达州杰克逊维尔诊所的一部分。据预计， 拟议的ADRC将扩大到包括杰克逊维尔在#年的活动 未来几年。

The proposed Mayo Clinic Alzheimer's Disease Research Center (ADRC) is designed to be a major patient evaluation, research, and education resource for the upper Midwest. Epidemiology studies utilizing the population data base at the Mayo Clinic have provided the first age- and sex-specific incidence rates in the United States for dementing illnesses. The Mayo Clinic ADRC will extend these epidemiologic studies through a prospective community survey to establish prevalence rates in the urban and rural populations of Olmsted County, Minnesota. Case/control studies have been designed to evaluate etiologic risk factors including familial aggregation, environmental, and occupational toxic exposures. In the course of the community survey, a large number of non-demented elderly subjects will be identified, and normative values for commonly used neuropsychological tests for the elderly and the very elderly (80 and over) will be established. A unique feature of this ADRC is its ability to compare a community based population with a referral population with respect to demographic and clinical characteristics as well as survivorship. A neuropharmacology research project will study muscarinic acetylcholine receptor subtypes in Alzheimer's disease. A neuroimaging project will correlate volumetric changes in medial temporal lobe structures as measured by magnetic resonance imaging and functional changes as measured by single photon emission computed tomography with neuropsychological, clinical, and demographic characteristics of Alzheimer's disease patients and normal controls in a longitudinal fashion. The primary focus of the proposed ADRC in the initial years will be to establish a regional referral center for patients with Alzheimer's disease. The Mayo clinic is expanding its commitment to alzheimer's disease research by establishing an Alzheimer's disease research facility as part of its Jacksonville, Florida, clinic. It is anticipated that the proposed ADRC will expand to encompass the Jacksonville activities in future years.