NEUROLOGIC COMPLICATIONS OF HIV

这个项目是由四个独立的研究组成 旨在探索一个高度综合的，多学科的 时尚，关于临床和 人类免疫缺陷病毒（HIV）相关基础科学 神经系统疾病 重点研究是对 无症状、艾滋病毒血清反应阳性者和性别、年龄与艾滋病 风险组匹配的神经系统发育对照 使用多个评估参数的疾病。 中 将解决的问题是， 神经系统疾病的发展与HIV感染有关， 这些疾病的自然史，以及 预测他们的发展。 详细的临床和实验室 用脑脊液（CSF）评价研究受试者 分析将使我们能够探索艾滋病毒相关的 神经系统疾病的艾滋病毒的存在和性质， 对HIV的免疫反应，巨细胞病毒（CMV）的存在 以及对CMV的免疫反应的性质，以及 脑反应性抗体

This program project is a composite of four separate studies designed to explore in a highly integrated, multidisciplinary fashion, certain fundamental issues regarding the clinical and basic science of human immunodeficiency virus (HIV)- related neurological disease. The key study is a longitudinal study of asymptomatic, HIV seropositive individuals and sex, age and AIDS risk group matched controls for the development of neurological disease utilizing multiple parameters of assessment. Among the issues that will be addressed are the frequency with which neurological disease develops in association with HIV infection, the natural history of these disorders, and the identification of predictors for their development. Detailed clinical and laboratory evaluation of the study subjects with cerebrospinal fluid (CSF) analysis will allow us to explore the relationship of HIV-related neurological disease to the presence of HIV and the nature of the immune response to HIV, the presence of cytomegalovirus (CMV) and the nature the immune response to CMV, and the presence of brain reactive antibody.