Defining the Interaction of HIV with the Interferon System in Initial Mucosal Infection

病毒暴露后很早，免疫细胞就会分泌干扰素，帮助限制病毒在体内的传播。我们将研究HIV和干扰素系统之间的复杂相互作用，特别是HIV如何抑制干扰素的早期诱导以帮助其传播，然后身体如何恢复干扰素的反应。我们还将研究HIV如何操纵干扰素系统，以保持组织内的潜伏库。

Very early after virus exposure, immune cells secrete interferons that help limit the spread of viruses within the body. We will investigate the complex interplay between HIV and the interferon system, especially how HIV inhibits the early induction of interferon to aid its spread and then how the body later restores the interferon response. We will also examine how HIV manipulates the interferon system in order to persistent latent reservoirs within tissues.