MyPEEPS Mobile LITE: Limited Interaction Efficacy Trial of MyPEEPS Mobile to Reduce HIV Incidence and Better Understand the Epidemiology of HIV among YMSM

MyPEEPS Mobile LITE：MyPEEPS Mobile 的有限交互功效试验可降低 YMSM 中的 HIV 发病率并更好地了解 HIV 流行病学

• 批准号: 10676911
• 负责人: Dustin T Duncan
• 金额: $ 199.81万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10676911
• 关键词: 18 year old; AIDS prevention; Accounting; Address; Advertisements; Advertising; Affect; Age; Age Years; Alcohol consumption; Anxiety; Behavior; Behavioral Model; Bisexual; Black race; Clinical Trials; Communities; Crime; Data; Discrimination; Electronics; Enrollment; Epidemic; Epidemiology; Ethnic Origin; Evidence based intervention; Exclusion; Facebook; Frequencies; Funding; Future; Gays; Geographic Locations; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; HIV diagnosis; HIV risk; Hot Spot; Incidence; Individual; Individual Differences; Instagram; Institution; Intervention; Intervention Studies; Knowledge; Latino; Literature; Measures; Mediator; Mental Depression; Methods; Modeling; Motivation; Neighborhoods; Outcome; Participant; Persons; Phase; Policies; Population; Positioning Attribute; Poverty; Predisposition; Prevalence; Prevention Research; Principal Investigator; Public Policy; Race; Randomized; Recording of previous events; Reporting; Research; Research Design; Research Personnel; Risk; Risk Reduction; Rural; Sample Size; Sampling; Science; Self Efficacy; Social support; Techniques; Testing; TikTok; Time; Treatment Efficacy; Twitter; United States; United States National Institutes of Health; Unsafe Sex; arm; behavior change; cisgender; cohort; condomless anal sex; digital; digital delivery; efficacy evaluation; efficacy testing; efficacy trial; epidemiology study; ethnic diversity; ethnic minority; evidence base; experience; health care service; health seeking behavior; high risk; innovation; innovative technologies; intervention effect; intimate partner violence; longitudinal analysis; mHealth; male; men who have sex with men; observational cohort study; peer; pre-exposure prophylaxis; preventive intervention; racial diversity; racial minority; recruit; research study; response; retention rate; same-sex partnership; seroconversion; sexual minority; sexual risk behavior; social; social media; social stigma; standard of care; substance use; success; theories; therapy development; transmission process; tribal lands; uptake; virtual; young men who have sex with men

PROJECT SUMMARY There is a critical need to better understand the epidemiology of HIV acquisition in the United States (US), particularly among cisgender gay, bisexual and other men who have sex with men (MSM), one of the key populations essential to target for End the HIV Epidemic (EHE) initiatives. In direct response to RFA-AI-21-018, this study will use innovative technology to recruit and retain a large cohort of high-risk, HIV-negative young men who have sex with men (YMSM) focusing on racial/ethnic minority YMSM and high HIV prevalence geographic areas (known as “hot spots”). Furthermore, we will leverage this cohort to conduct a large-scale clinical trial while maintaining the standard of care control arm as a longitudinal observational cohort for epidemiologic analyses. Our study team is uniquely positioned and has all the relevant expertise to conduct this study having successfully recruited and retained more than 12,000 YMSM in a full range of research studies across the HIV continuum (e.g., epidemiology, intervention development, mHealth, PrEP, clinical trials, innovative geospatial methods). We have had specific success conducting prevention research with YMSM (17-25 years), including racially and ethnically diverse YMSM, our target demographic group. Further, we have previously leveraged advanced social media advertising techniques and used innovative geospatial analytics to target/study “communities within communities”, reaching hard-to-reach YMSM from diverse geographic areas (e.g., rural zip codes, U.S. tribal lands, etc.) and young ages (e.g., YMSM 13-18 years of age). We will harness innovative technology to recruit, during 36-months of enrollment, and then retain a large cohort (N = 5,000) of 17-25 year old YMSM, the majority being Black and Latino, who are at high-risk of HIV transmission (e.g., history of condomless anal sex) and follow them every 6 months thereafter. We will conduct an entirely virtual, digital clinical trial (Specific Aim #1) testing whether MyPEEPS Mobile (an evidence-based mHealth HIV prevention intervention) reduces HIV incidence among HIV-negative YMSM (17-25 years old) looking at the influence of theory-driven social, ecological, and geospatial factors on intervention uptake and efficacy inclusive of measures that align with traditional models of behavior change such as the Information Motivation Behavior Model. A social-ecological theoretical framework will also guide the analysis of the longitudinal observational cohort study (Specific Aim #2) of the 2,500 control arm participants to assess individual, network, geospatial, and public policy correlates of HIV risk and health seeking behaviors (e.g., PrEP uptake) comparing individuals who become HIV-positive to those who do not. Intervention Implications. The findings from this research will have important real-world implications for research and practice. For example, understanding how individual, network, geospatial, and public policy factors correlate with HIV incidence and moderate intervention effects will help inform how and where interventions should be delivered.

项目总结