Defining key determinants of HLA mediated T cell tolerance and autoimmunity

当免疫系统出现故障时，它会导致身体失去一种或多种自身蛋白质的耐受性，导致影响5%以上人口的自身免疫性疾病。这个项目使用自身免疫性肾脏疾病来研究为什么我们会失去对自己的耐受性。了解这一过程不仅是确定自身免疫性疾病基础的基础，也是未来开发更有效、更有针对性和毒性更小的治疗方法的关键一步。

When the immune system malfunctions it can cause the body to lose tolerance one or more of its own proteins, leading to autoimmune diseases that affect more than 5% of the population. This project uses autoimmune kidney disease to study why we lose tolerance to ourselves. Understanding this process is not only fundamental to defining the basis of autoimmune diseases but also a key step in the development of more effective, more targeted and less toxic therapies in the future.