CD SPECTROMETER

请求提供资金，以购买一台圆二色光谱仪 具有出色的远紫外线能力。 该设备需要填充一个 基本仪器存在重大差距。 远紫外线能力是 生物大分子的结构研究必不可少，这些 任何目前可用的CD光谱仪都不能满足这些需求。 CD将用于监测肽的结构转变， 被捕获的蛋白质折叠中间体的结构，结构方面 蛋白质变构转换，以及药物对DNA的影响 结构 主要用户包括生物化学系的五个系 系和化学系的两名教员。 本文书 将由一个内部咨询委员会管理， 路易斯安那州立大学基础科学学院的仪器 大学

Funds are requested to purchase a Circular Dichroism (CD) Spectrometer with excellent far UV capabilities. This equipment is needed to fill a significant gap in basic instrumentation. The far UV capabilities are essential for structural studies of biological macromolecules, and these needs cannot be fulfilled by any currently available CD spectrometer. The CD will be used to monitor structural transitions in peptides, structures of trapped protein folding intermediates, structural aspects of protein allosteric transitions, and effects of drugs on DNA structure. The main users include five faculty in the biochemistry department and two faculty in the chemistry department. This instrument will be administered by an internal advisory committee as a shared instrument in the College of Basic Sciences at Louisiana State University.