Defining the Physiology and Therapeutic Potential of Inhibin

更年期卵巢功能的关闭消耗了女性体内循环的雌激素和抑制素。虽然我们知道雌激素缺乏对骨骼健康有害，但对抑制素丧失的影响却知之甚少。我制造了一只缺乏功能性抑制素的老鼠，这样我们就能了解在更年期抑制素缺失对全身的影响。此外，我已经找到了一种大规模生产抑制素的方法，使我们能够探索抑制素替代疗法的潜力。

Shutdown of ovarian function at menopause depletes the female body of circulating oestrogen and inhibins. Whilst it is known that oestrogen deprivation is bad for bone health, little is known about the impact of inhibin loss. I have made a mouse that lacks functional inhibins, so that we can understand the body wide consequences of inhibin loss at menopause. Additionally, I have found a way to mass produce inhibins, allowing us to explore the potential of inhibin replacement therapies.