Effect of Inorganic Nitrite on Cardiac and Skeletal Muscle: Physiology, Pharmacology and Therapeutic Potential

无机亚硝酸盐对心脏和骨骼肌的影响：生理学、药理学和治疗潜力

• 批准号: G1001536/2
• 负责人: Michael Frenneaux
• 金额: $ 131.31万
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1001536%2F2
• 关键词: Effect; Inorganic; Nitrite; Cardiac; Skeletal

Consumption of green vegetables and beetroot increases the concentration in the bloodstream of a chemical called nitrite. Recent evidence suggests that when the cncentration of this chemical is increased by dietary means muscle works more efficiently and requires less oxygen. We will investigate why this occurs. Heart muscle is another type of muscle and we will investigate whether nitrite has a similar effect in heart muscle. Finally we will investigate whether this can be exploited as a treatment in conditions such as blockage of the arteries of the leg and the heart.

食用绿色蔬菜和甜菜根会增加血液中一种名为亚硝酸盐的化学物质的浓度。最近的证据表明，当这种化学物质的浓度通过饮食增加时，意味着肌肉的工作效率更高，需要的氧气更少。我们将调查为什么会发生这种情况。心肌是另一种类型的肌肉，我们将研究亚硝酸盐在心肌中是否有类似的作用。最后，我们将研究这是否可以用于治疗腿部和心脏动脉阻塞等情况。