ROLE OF THE ARTERIAL WALL IN ATHEROSCLEROSIS

该方案项目的目的是增进对 高血压和动脉粥样硬化血管发病机制的研究进展 疾病，尤指冠状动脉和脑血管疾病。在……里面 为了实现这一目标，正在对非人类进行研究 实验动物模型(食蟹猴) 动脉粥样硬化和/或高血压和组织培养模型 使用平滑肌细胞和巨噬细胞。动脉粥样硬化 这只猴子是通过手术缩窄胸主动脉而产生的。 该计划的具体目标是确定(1)效果 高胆固醇血症饮食和/或高血压 食蟹鱼循环免疫复合体水平的研究 (2)免疫因素的参与。 动脉粥样硬化与高血压的相关性研究 血管和循环中的免疫学表现 根据实验中诱发的 血管疾病；(3)脂蛋白复合体 包含在人类动脉粥样硬化斑块中的是自身免疫 载脂蛋白和抗载脂蛋白复合体 抗体；(4)动脉粥样硬化和高血压对血管病变的影响 食蟹猴主动脉组织中胶原基因的表达； (5)I型和II型胶原蛋白的生产和 处理弹性蛋白的合成、分泌和积累 血管平滑肌细胞；(6)血管紧张素转换酶的机制 赖氨酰氧化酶的生物合成途径的控制 在培养的主动脉平滑肌细胞(SMC)中合成； 大鼠赖氨酸氧化酶活性控制水平的类固醇特异性 培养SMC；(8)结缔组织的生物合成 响应中的矩阵开发过程中的组件 对基质损伤的影响；(9)蛋白水解性或机械性损伤的影响 关于SMC培养对I型和I型的调节 III型胶原基因与细胞增殖；(10)分泌和 平滑肌细胞来源的泡沫细胞的吞噬功能。 非人灵长类动物模型和组织培养的应用 模型被认为代表了一种重要而有效的 从组织、细胞角度探讨血管疾病的研究 和分子水平。

The object of the program project is to enhance the understanding of the pathogenesis of hypertensive and atherosclerotic vascular disease particularly of the coronary and cerebral vessels. In achieving the objective, studies are being conducted in nonhuman primate models (cynomolgus monkey) with experimental atherosclerosis and/or hypertension and in tissue culture models using smooth muscle cells and macrophages. Atherosclerosis in the monkey is produced by surgically coarcting the thoracic aorta. The specific aims of the program are to determine (1) the effects of hypercholesterolemic atherogenic diet and/or hypertension on the levels of circulating immune complexes in the cynomolgus monkey; (2) the participation of immunological factors in atherosclerosis and its aggravation by hypertension by correlating the immunological findings in the blood vessels and circulation with the extent and severity of the experimentally induced vascular disease; (3) whether the lipid-protein complexes contained in human atherosclerotic plaques are autoimmune complexes consisting of apolipoproteins and anti-apolipoprotein antibodies; (4) effects of atherosclerosis and hypertension on collagen gene expression in the cynomolgus monkey aortic tissue; (5) the production of Type I and II collagen protein and the processing elastin synthesis, secretion and accumulation in vascular smooth muscle cells; (6) the nature of the mechanisms of control of the biosynthetic pathway in which lysyl oxidase is synthesized in cultured aortic smooth muscle cells (SMC); (7) the steroid specificity of the control levels of lysyl oxidase activity in cultured SMC; (8) the biosynthesis of the connective tissue components during the course of matrix development in response to matrix injury; (9) the effect of proteolytic or mechanical injury to SMC culture with respect to the regulation of Type I and Type III collagen genes and cell proliferation; (10) secretory and phagocytic function of the smooth muscle cell derived foam cell. The use of non-human primate models as well as tissue culture models is believed to represent an important and effective approach to the study of vascular disease at the tissue, cellular and molecular level.