Defining role of inflammatory signals in enhancing motoneuron regeneration

脊髓损伤是一种毁灭性的事件，对患者的生活产生终身影响，并产生广泛的社会和经济影响。在这个提议中，我们研究了炎症信号如何促进损伤后的神经元再生。此外，我们定义了新的神经元如何能够整合到现有的脊髓回路。我们的工作提供了关键的洞察力，并掌握了解锁未来大脑或脊髓恢复治疗策略的钥匙。

Spinal cord injury is a devastating event that has a life-long impact on the patient’s life with wide-reaching social and economic effects. In this proposal we examine how inflammatory signals boost neuronal regeneration after injury. Furthermore, we define how new neurons are able to integrate into existing spinal circuitry. Out work provides critical insight and hold keys to unlocking strategies for future restorative therapies in the brain or spinal cord.