DUKE UNIVERSITY MEDICAL CENTER FOR AIDS RESEARCH

申请在杜克大学建立艾滋病研究中心 在六年内汇集了三十多名独立调查人员的才华 学术部门。所有人都从事艾滋病或艾滋病相关研究。 代表了多个学科，但科学计划 分为四大领域：(1)宿主-HIV-1的分子机制 相互作用，(2)HIV蛋白的免疫原性表位，(3)细胞 对HIV-1感染的反应和(4)其他人类逆转录病毒和 HIV-1致病性中的感染源。基础科学计划 与临床研究计划密切互动，该计划包括 成人和儿科部件。基础和临床研究计划 由在(1)基因中提供支持的七个核心资源提供动力 表情。(2)肽合成，(3)逆转录病毒生物学，(4)流 细胞学，(5)SCID-Hu/转基因小鼠模型，(6)数据管理和(7) 采购人体研究材料和方案设计。剩下的 各组成部分代表对未来增长和发展的计划、评价 和行政管理。

This application to develop a Center for AIDS Research at Duke University assembles the talents of over thirty independent investigators within six academic departments. All are engaged in AIDS or AIDS related research. Multiple disciplines are represented but the scientific programs are organized into four broad areas: (1) molecular mechanisms of host-HIV-1 interactions, (2) immunogenic epitopes of HIV proteins, (3) cellular responses to HIV-1 infection and (4) other human retroviruses and infectious agents in HIV-1 pathogenicity. The basic science programs interact closely with the clinical research program which includes both adult and pediatric components. Both basic and clinical research programs are fueled by seven core resources which provide support in (1) gene expression. (2) peptide synthesis, (3) retroviral biology, (4) flow cytometry, (5) Scid-Hu/transgenic mouse models, (6) data management and (7) procurement of human research material and protocol design. The remaining components represent plans for future growth and development, evaluation and administration.