NUCLEAR MAGNETIC RESONANCE SUPERCONDUCTING MAGNET

此应用程序的目的是申请资金以升级 现有1.9特斯拉全身局部磁共振(TMR)磁体 3.0特斯拉用于核电应用的整体“扁平”磁铁 磁共振波谱和成像技术在生物医学研究中的应用 脑代谢、脑血流和肿瘤对治疗的反应。我们的 目前的磁体利用TMR技术作为一种光谱手段 本地化。在安装这块磁铁时，TMR是唯一的 可用于非侵入性光谱定位的手段。虽然TMR 在体内核磁共振发展的初始阶段是有用的 光谱学，它现在被认为是过时的技术，并已成为 不如更有效的卷定位技术，后者使用 切换线性磁场梯度(例如，体内图像选择性 光谱学，ISIS)。我们现在的磁铁是这类磁铁中唯一的磁铁 利用TMR作为人体光谱定位的主要手段 活体光谱。 目前的TMR磁体是100%用于研究的。升级到3.0 特斯拉扁平磁铁也将100%致力于研究，并将提供 美国国立卫生研究院的这个集中小组支持研究人员获得核磁共振 可以执行最先进的光谱分析和成像的系统。

The purpose of this application is to request funds for the upgrade of an existing 1.9 Tesla whole-body Topical Magnetic Resonance (TMR) magnet to a 3.0 Tesla whole-body "flat" magnet for the purpose of applying Nuclear Magnetic Resonance spectroscopy and imaging technology to the study of brain metabolism, cerebral blood flow, and tumor response to therapy. Our present magnet utilizes the technology of TMR as a means of spectroscopic localization. At the time of installation of this magnet, TMR was the only available means for non-invasive spectroscopic localization. Although TMR has been useful in the initial stages of the development of in vivo NMR spectroscopy, it is now considered obsolete technology, and has become inferior to the more efficient volume localization techniques which use switched linear magnetic field gradients (e.g. Image Selective In-Vivo Spectroscopy, ISIS). Our present magnet is now the only magnet of its kind using TMR as the primary means of spectroscopic localization for human in vivo spectroscopy. The present TMR magnet is 100% research dedicated. The upgrade to a 3.0 Tesla "flat" magnet will also be 100% research dedicated, and will provide this concentrated group of NIH supported researchers access to an NMR system which can perform state-of-the-art spectroscopy and imaging.