课题基金 / 基金详情

DEVELOPMENT OF DRUGS ACTION AT ADENOSINE RECEPTORS

DEVELOPMENT OF DRUGS ACTION AT ADENOSINE RECEPTORS
腺苷受体药物作用的开发
批准号：
3897061
负责人：
K JACOBSON
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3897061
关键词：
adenosine cardiovascular disorder chemotherapy drug design /synthesis /production drug screening /evaluation endocrine disorder hemodynamics immunomodulators immunopathology chemotherapy nervous system disorder chemotherapy neurotransmitters

项目摘要

项目成果

K JACOBSON的其他基金

相关文献

中文摘要
翻译
细胞外腺苷受体在神经系统中具有调节作用， 循环、内分泌和免疫系统。的前景 将这些效应专门用于治疗目的， 吸引人. 药物设计的功能化同源物方法已被应用于 腺苷受体产生激动剂和拮抗剂的类似物， 有希望作为治疗剂和受体探针。在 拮抗剂系列新的类似物，其结合了联合收割机的效力、水溶性和 A1 -腺苷受体在同一化合物的选择性，现在正在 在体内测试中进行了评估。
英文摘要
The extracellular adenosine receptor has a modulatory role in the nervous, circulatory, endocrine, and immunological systems. The prospect of harnessing these effects specifically for therapeutic purposes is attractive. A functionalized congener approach to drug design has been applied to the adenosine receptor to produce analogs of agonists and antagonists which have promise as therapeutic agents and as receptor probes. In the antagonist series new analogs which combine potency, water solubility, and A1 -adenosine receptor selectivity in the same compound are now being evaluated in in vivo testing.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
FUNCTIONALIZED CONGENERS OF BIOACTIVE COMPOUNDS
FUNCTIONALIZED CONGENERS OF BIOACTIVE COMPOUNDS
FUNCTIONALIZED CONGENERS OF BIOACTIVE COMPOUNDS
DEVELOPMENT OF DRUGS ACTING AT ADENOSINE RECEPTORS