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DEVELOPMENT OF DRUGS ACTION AT ADENOSINE RECEPTORS

DEVELOPMENT OF DRUGS ACTION AT ADENOSINE RECEPTORS
腺苷受体药物作用的开发
批准号：
3875625
负责人：
K JACOBSON
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3875625
关键词：
adenosine cardiovascular agents cardiovascular disorder chemotherapy drug design /synthesis /production drug screening /evaluation drug vehicle endocrine disorder hemodynamics immunomodulators immunopathology chemotherapy nervous system disorder chemotherapy neuropharmacologic agent neurotransmitters nucleobase analog receptor

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中文摘要
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英文摘要
The extracellular adenosine receptor has a modulatory role in the nervous, circulatory, endocrine, and immunological systems. The prospect of harnessing these effects specifically for therapeutic purposes is attractive. A functionalized congener approach to drug design has been applied to the adenosine receptor to produce analogs of agonists and antagonists which have promise as therapeutic agents and as receptor probes. Prodrugs of adenosine agonists and antagonists targeted for the brain and kidneys are being designed. In the antagonist series new analogs which combine potency, water solubility, and A(1)-adenosine receptor selectivity in the same compound are now being evaluated in in vivo testing.
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FUNCTIONALIZED CONGENERS OF BIOACTIVE COMPOUNDS
FUNCTIONALIZED CONGENERS OF BIOACTIVE COMPOUNDS
FUNCTIONALIZED CONGENERS OF BIOACTIVE COMPOUNDS
DEVELOPMENT OF DRUGS ACTING AT ADENOSINE RECEPTORS
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