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DEVELOPMENT OF DRUGS ACTION AT ADENOSINE RECEPTORS

DEVELOPMENT OF DRUGS ACTION AT ADENOSINE RECEPTORS
腺苷受体药物作用的开发
批准号：
3875625
负责人：
K JACOBSON
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3875625
关键词：
adenosine cardiovascular agents cardiovascular disorder chemotherapy drug design /synthesis /production drug screening /evaluation drug vehicle endocrine disorder hemodynamics immunomodulators immunopathology chemotherapy nervous system disorder chemotherapy neuropharmacologic agent neurotransmitters nucleobase analog receptor

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中文摘要
翻译
细胞外腺苷受体在神经系统中具有调节作用， 循环、内分泌和免疫系统。的前景 将这些效应专门用于治疗目的， 吸引人. 药物设计的功能化同源物方法已被应用于 腺苷受体产生激动剂和拮抗剂的类似物， 有希望作为治疗剂和受体探针。的前药 靶向脑和肾的腺苷激动剂和拮抗剂 正在设计中。在拮抗剂系列中，新的类似物结合了联合收割机的效力， 水溶性和A（1）-腺苷受体选择性 化合物现在正在体内测试中进行评估。
英文摘要
The extracellular adenosine receptor has a modulatory role in the nervous, circulatory, endocrine, and immunological systems. The prospect of harnessing these effects specifically for therapeutic purposes is attractive. A functionalized congener approach to drug design has been applied to the adenosine receptor to produce analogs of agonists and antagonists which have promise as therapeutic agents and as receptor probes. Prodrugs of adenosine agonists and antagonists targeted for the brain and kidneys are being designed. In the antagonist series new analogs which combine potency, water solubility, and A(1)-adenosine receptor selectivity in the same compound are now being evaluated in in vivo testing.
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FUNCTIONALIZED CONGENERS OF BIOACTIVE COMPOUNDS
FUNCTIONALIZED CONGENERS OF BIOACTIVE COMPOUNDS
FUNCTIONALIZED CONGENERS OF BIOACTIVE COMPOUNDS
DEVELOPMENT OF DRUGS ACTING AT ADENOSINE RECEPTORS
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