THE UNIVERSITY OF MICHIGAN MULTIPURPOSE ARTHRITIS CENTER

该提案提出了进一步发展 密歇根大学多功能关节炎中心（UMAC）。 骨关节炎（OA）将在试点中得到特别重视 研究领域和主要流行病学研究。 整体 UMAC的目标继续包括：1）基础和临床 研究处理的发病机制和治疗的几个 风湿性疾病; 2）继续教育/培训计划 医生和其他卫生专业人员，以满足学术 和病人的护理需求在外地; 3）发展新的 针对特定目标群体的教育方案; 4）扩大 一个独特的以社区为基础的初级保健教育方案 医生;和5）最好的每一个教育工作的评价 可用的方法。 已建立的研究计划将 辅以9个新的试点研究项目，这些项目涉及： 骨关节炎动物模型，骨关节炎生化机制，新影像学 OA相关技术，免疫细胞的三种不同研究 受体功能、幼年关节炎的HLA-DR表型以及 病毒诱导的多发性肌炎小鼠模型。 六新教育 项目对象：体育领域的教师， 类风湿性关节炎的治疗方法 关节炎，初级保健医师学员，青少年关节炎 公立学校环境中的患者，以及类风湿 采用非手术方法治疗钮扣状畸形的患者。 在社区计划组成部分的关键因素的新研究 这决定了初级保健医生参与继续 提出了在风湿病学领域开展医学教育的建议。 它将利用以前收集的CME数据，并确定 新的信息如何到达初级保健医生。 的 密歇根州特库姆塞的人口将被重新检查，以衡量 骨关节炎的发病率、消退和进展， 骨质疏松症与20年前（1962-65）的结果相比。 整个密歇根州的随机概率样本将 也可以研究，以提供这两个条件的估计， 并确定可能的干预措施 战略布局 这些研究、教育和社区项目将 由一个行政股提供支助，该股并入 建立了大学的组织。 特殊的纸巾 文化核心股拟予续设，因为它支持 该中心的几个已建立的研究项目。 UMAC得到了私人和国家机构的外部支持， 以及所需的机构支持，专业的，物质的， 和患者资源，以实现其既定目标。

This proposal sets forth a plan for further development of the University of Michigan Multipurpose Arthritis Center (UMAC). Osteoarthritis (OA) is to receive special emphasis in the pilot research area and in a major epidemiologic study. The overall objectives of UMAC continue to include: 1) basic and clinical research dealing with the pathogenesis and treatment of the several rheumatic diseases; 2) continuation of education/training programs for physicians and other health professionals to meet the academic and patient care needs in the field; 3) development of new education programs for specific target groups; 4) expansion of a unique program of community-based education for primary care physicians; and 5) evaluation of each education effort by the best available methodology. Established research programs will be complemented by 9 new pilot research projects that deal with: a new animal model of OA, biochemical mechanisms in OA, new imaging techniques relevant to OA, three different studies of immune cell receptor function, HLA-DR phenotypes in juvenile arthritis, and a virus-induced murine model of polymyositis. Six new educational projects target: teachers in the field of physical education, University students with rheumatoid disease, adults with rheumatoid arthritis, primary care physician trainees, juvenile arthritis patients in the public school setting, and assessment of rheumatoid patients with boutonniere deformities treated by nonsurgical means. In the community programs component a new study of critical factors which determine primary care physician involvement in continuing medical education (CME) in the field of rheumatology is proposed. It will utilize previously collected CME data and also determine how new information reaches the primary care practitioner. The population of Tecumseh, Michigan will be re-examined to measure the incidence, regression, and progression of osteoarthritis and osteoporosis as compared to findings 20 years previously (1962-65). A random probability sample of the entire state of Michigan will also be studied to provide estimates of these two conditions in the general population and to identify possible intervention strategies. These research, education, and community projects will be supported by an Administrative Unit that is integrated into the established organization of the University. A special Tissue Culture Core Unit is proposed for continuation since it supports several of the established research programs within this Center. UMAC has the external support of private and state agencies, as well as the required institutional support, professional, physical, and patient resources to achieve its stated objectives.