Delineating the role of advanced glycation in diabetes and nephropathy

1型糖尿病影响了超过14万澳大利亚人，其中高达40%的儿童和青少年患有包括肾脏疾病在内的并发症。糖尿病导致的血糖过高会加速一种被称为晚期糖基化的生化过程，这种生化过程会永久性地改变蛋白质，影响它们的结构和功能，我之前已经证明了这是糖尿病患者肾脏损伤的原因。然而，最近，我发现这个生化过程也参与了1型糖尿病本身的发展。

Type 1 diabetes affects more than 140,000 Australians and up to 40% of children and adolescents with the disease develop complications including kidney disease. Excess blood sugar as the result of diabetes can accelerate a biochemical process called advanced glycation, which permanently alters proteins affecting their structure and function, which I have previously shown as contributors to kidney damage in diabetes. Recently, however, I have discovered that this biochemical process is also involved in the development of type 1 diabetes itself.