GENERAL CLINICAL RESEARCH CENTER

这项更新提案要求NIH支持一个八张病床的普通 南卡罗来纳州医科大学临床研究中心。 主要研究领域包括：矿物质代谢及其在健康中的调节 糖尿病血小板聚集;设计和评价 神经转运抑制剂药物;白藜芦醇和肾水的控制 排泄;正常和高血压父母子女的盐代谢; 肾上腺素能神经元作为普萘洛尔的储存和释放部位;检测 结缔组织疾病的特征;激肽释放酶-激肽系统 肾功能、高血压等疾病;以及新陈代谢， 普萘洛尔立体异构体在正常人和 高血压的人 拟议的工作将在一个环境中进行， 基础生物医学科学家和临床 investigators. 分析和合成化学及生物化学是 这对该综合临床研究中心的工作至关重要。

This renewal proposal is requesting NIH support for an eight bed General Clinical Research Center at the Medical University of South Carolina. Major areas of study include: mineral metabolism and its regulation in health and diseases; platelet aggregation in diabetes mellitus; design and evaluation of neurotranshibitor drugs; prostaglandins and the control of renal water excretion; salt metabolism in children of normal and hypertensive parents; the adrenergic neuron as a storage and release site of propranolol in man; detection and characterization of connective tissue disease; the kallikrein-kinin system in renal function, hypertensive and other diseases; and the metabolism, pharmacokinetics and pharmacodynamics of propranolol stereoisomers in normal and hypertensive man. The proposed work is to be carried out in an environment which emphasizes interdisciplinary collaboration between basic biomedical scientists and clinical investigators. Analytical and synthetic chemistry and biochemistry are of central importance to the work in this General Clinical Research Center.