X-RAY STRUCTURE DETERMINATION SYSTEM

请求为最先进的综合X光结构提供资金 测定和分析系统，具有：计算机控制的 具有高强度旋转阳极X射线源的衍射仪; 在低温下收集X射线数据的能力;快速多 一种用户微型计算机，带有用于存储和操作的大磁盘 结构数据库。 该研究设备将用于多个 不同的项目。 其中包括：有机硫的结构研究 化合物和有机硒化合物的结构研究 含铼酶的金属中心模型;低- 不饱和脂肪酸的温度结构研究和不对称 （混合链）磷脂;构象的结构研究 限制性肽和激素， 通过生物信使传递，用于比较固态和 溶液结构，并用于设计具有上级 生物和药用特性;天然药物的结构研究 产品、抗肿瘤药物和抗生素;相互作用建模 药物与大分子的结合，特别是抗肿瘤药物与大分子的结合， 脱氧核糖核酸因子;特定分子畸变与化学 高分辨实验电子密度 有机硫化合物、金属-硫键和硫氧化物模型的研究 钼酶

Funding is requested for an integrated state-of-the-art x-ray structure determination and analysis system possessing: a computer controlled diffractometer with a high intensity rotating anode x-ray source; capabilities for collection of x-ray data at low temperature; a fast multi- user microcomputer with a large disk for storing and manipulating structural data bases. This research equipment will be used for several diverse projects. These include: structural studies of organo sulfur compounds and organo selenium compounds; structural studies of synthetic models for the metal centers of molybdenum-containing enzymes; low- temperature structural studies of unsaturated fatty acids and asymmetric (mixed-chain) phospholipids; structural studies of conformationally constrained peptides and of hormones, for understanding information transfer by biological messengers, for comparison of solid state and solution structures, and for designing new compounds with superior biological and medicinal properties; structural studies of natural products, antitumor agents, and antibiotics; modeling the interactions between drugs and macromolecules, especially the binding of antitumor agents to DNA; correlation of specific molecular distortions with chemical and biological activity; high resolution experimental electron density studies of organo sulfur compounds, metal-sulfur bonds, and models for molybdenum enzymes.