MOLECULAR GENETIC ANALYSIS OF FELINE CELLULAR GENES--A COMPARATIVE APPROACH

国内已建立了60多个基因座的遗传图谱。 猫。猫科动物之间的连锁同源性达到了惊人的程度 人类的地图被发现了，这是三到四次 比从老鼠到人类的遗传同步性更保守 (连锁同源)。近40%的人类细胞学图谱 可以逐个频段对齐，具有同源的 猫的染色体。这种程度的连锁同源性被用来 估计人类白化病基因座的染色体位置并 原癌基因家族转位检测 8000万年的进化，从人类开始 猫和猫有共同的祖先。三个人的组织 研究发现，不同的内源性逆转录病毒家族 与其他哺乳动物的内源性逆转录病毒家族相似 物种，包括人类。遗传基因座，它编码一系列 人类猫科动物模型中的溶酶体酶 神经储存疾病，已经被局部化了。一种分子 猫科的系统发育是基于三个 方法学和猫科进化的细胞遗传学描述 是发展起来的。

A genetic map of over 60 loci has been developed in the domestic cat. A remarkable extent of linkage homology between the feline and human maps was discovered which was three to four times more conserved than the mouse-to-human genetic synteny (linkage homology). Nearly 40% of the human cytological map can be aligned, band-for-band, with syntenically homologous feline chromosomes. This degree of linkage homology was used to estimate chromosomal location of the human albino locus and to test for transposition of the proto-oncogene family during the over 80 million years of evolution which has elapsed since man and cat shared a common ancestor. The organization of three distinct endogenous retroviral families was studied and found to resemble endogenous retroviral families in other mammalian species, including man. Genetic loci, which encode a series of lysosomal enzymes involved in feline models of human neurological storage diseases, have been localized. A molecular phylogeny of the Felidae family has been derived based upon three methodologies, and a cytogenetic description of Felidae evolution was developed.