A RESOURCE FOR BIOMEDICAL COMPUTING 20.

要求继续支持生物技术资源， 服务于华盛顿大学医学院和国家 通过合作研究。 该计划促进了生物医学 通过将最先进的计算技术带到 生物医学环境 研究活动包括理论 发展，基本的数字设计，生物信号的处理， 生物医学研究概念信息系统的发展 应用，并在商业和工业领域部署完整的系统， 全国的大学环境 具体目标是发展数字化 计算技术包括算法和计算机系统的发展 针对心电图的高速分析，研究了广义信源编码 对于数据压缩，断层图像的算法开发 重建、开发探测器性能评估模型， 采用超大规模集成电路的分布式多处理机系统的实现 设计和数据库机制的设计研究。 具体目标 与生物医学科学家的合作跨越基础科学， 临床医学 建议的项目包括实施和研究 用于疾病管理和研究的医学数据库，设计和 正电子发射轴向断层摄影系统的构造 光子飞行时间测量，实现一种新的方法， 辐射剂量估计采用专门的硬件，颜色 使用计算机控制的视频显示器绘制视野， 神经解剖放射自显影分析， 用于DNA限制性图谱的自动电泳凝胶阅读，和 采用高速心电图分析的多项当地和国家研究。 为用户提供服务的具体目标提供了灵活的特设 生物医学计算科学家培训安排 强调短期课程和研讨会;传播目标包括 算法、设备和 完整的系统。

Continuation support is requested for a biotechnology resource which serves the Washington University School of Medicine and the national community through collaborative research. The program advances biomedical research by bringing state-of-the-art computing techniques to the biomedical environment. Research activities embrace theoretical developments, basic digital designs, processing of biological signals and conceptual information system developments for biomedical research applications, and the fielding of complete systems in the commercial and university environments nationally. Specific aims to develop digital computing technologies include algorithm and computer system developments for high-speed analysis of ECGs, research on generalized source encoding for data compression, algorithm developments for tomographic image reconstruction, development of a detector-performance evaluation model, implementation of distributed multiprocessor systems incorporating VLSI designs, and design studies of database mechines. Specific aims for collaborations with biomedical scientists span basic sciences through clinical medicine. Proposed projects include the implementation and study of medical databases for disease management and research, design and construction of a positron-emission transaxial tomography system employing photon time-of-flight measurements, implementation of a new method for 3-D radiation dose estimation which employs specialized hardware, color mapping of visual fields using computer controlled video displays, analysis of neuroanatomical autoradiographs, development of a system for automated electrophoretic gel reading for DNA restriction mapping, and multiple local and national studies employing high-speed ECG analysis. Specific aims for offering services to users provide flexible ad hoc arrangements; those for training scientists in biomedical computing emphasize short courses and seminars; and aims for dissemination include publications, presentations and export of algorithms, devices, and complete systems.