SIMIAN RETROVIRUSES

D型猿猴逆转录病毒（SRVs）继续在地方性感染 ORPRC的Macaca fuscata、Macaca mulatta和Macaca nigra。 存在代表三个血清学组的四种不同的SRV 一个或多个物种。 这些SRV的密切相关变体是 也在场。 类型之间的直接因果关系 D SRVs和猿免疫缺陷综合征（SAIDS）几乎是 确定。 疾病的表达（或缺乏）可能取决于 感染性的变异体和物种。 机制 导致免疫缺陷的原因在很大程度上是未知的。 继续 拟议的监督和管理计划可能会导致 在建立无D型SRV猕猴群体中的作用。 研究提出了表征合成的SRV-2包膜 肽，细胞嗜性的SRVs，和分子差异 在变异病毒的包膜区，与不同的疾病 表情 重点是表征病毒宿主细胞 决定宿主中哪些细胞被靶向的相互作用 作为定义负责以下方面的机制的一个步骤 免疫抑制

Type D simian retroviruses (SRVs) continue to endemically infect Macaca fuscata, Macaca mulatta, and Macaca nigra at the ORPRC. Four distinct SRVs representing three serologic groups are present in one or more species. Closely related variants of these SRVs are also present. A direct cause and effect relationship between type D SRVs and simian immunodeficiency syndrome (SAIDS) is almost certain. Expression of disease (or lack of) is likely dependent on the infecting variant of SRV and species. The mechanism(s) leading to immunodeficiency are largely unknown. Continuation of proposed surveillance and management programs will likely result in the establishment of type D SRV-free macaque colonies. Studies are proposed to characterize synthetic SRV-2 envelope peptides, cellular tropism of SRVs, and the molecular differences in the envelope region of variant viruses, with different disease expression. The focus is to characterize the virus-host cell interactions that determine which cells in the host are targeted by type D SRVs as a step in defining mechanisms responsible for immunosuppression.