COMPUTER FOR ULTRASTRUCTURE RESEARCH & MOLECULAR BIOLOGY

要求支助一个为小组服务的计算机设施， 美国国立卫生研究院赠款的超微结构项目的主要研究者 研究和分子生物学。 重点是结构生物学领域的项目， 传统的电子显微镜和计算机断层扫描， 高压电子显微镜 生物学的范围 这些项目所涵盖的结构包括核糖体， 酶复合物，纤毛，有丝分裂器的组成部分， 和全细胞重建。 这些项目涉及以下问题： 大分子复合物的基本结构， 细胞器以及特定疾病和发育 流程. 其中大多数基于计算机的组件 项目依赖于光栅图形的可用性，大磁盘 空间和记忆。 使用共用设施是适当的 因为大部分现有的内部开发的软件 写这本书的目的是为了适应广泛的 应用程序，因为这样的设施导致最 资源的有效利用。

Support is requested fro a computer facility serving the group of principal investigators of NIH grants in projects of ultrastructural research and molecular biology. Emphasis is on projects in the areas of structural biology using the conventional electron microscope and computer tomography using the high voltage electron microscope. The range of biological structures encompassed by these projects include ribosomes and enzyme complexes, cilia, components of the mitotic apparatus, and whole cell reconstructions. The projects relate to issues of the fundamental structure of macromolecular complexes and organelles as well as to specific disease and developmental processes. Most of the computer-based components of these projects rely on the availability of raster graphics, large disk space and memory. The use of a shared facility is appropriate because the bulk of the existing software developed in-house has been written with a view towards accommodating a wide range of applications, and because such a facility leads to the most efficient utilization of resources.