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PROTEIN TRANSLATION INITIATION FACTOR 4D--STRUCTURE, BIOSYNTHESIS AND CONTROL

PROTEIN TRANSLATION INITIATION FACTOR 4D--STRUCTURE, BIOSYNTHESIS AND CONTROL
蛋白质翻译起始因子 4D——结构、生物合成和控制
批准号：
3939946
负责人：
M H PARK
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3939946
关键词：
aminoacid aminoacid biosynthesis aminoacid metabolism chemical structure function eukaryote genetic translation hydroxylation lysine polyamines spermidine

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中文摘要
翻译
真核蛋白翻译起始因子4D （eIF-4D）
英文摘要
Eukaryotic protein translation initiation factor 4D (eIF-4D) contains one residue of hypusine and appears to be the only cellular protein with this one unique amino acid. Hypusine is produced posttranslationally by transfer of the butylamine portion of the polyamine spermidine to a lysine residue in the eIF-4D precursor and subsequent hydroxylation. These findings reveal a novel cellular metabolic pathway. Studies are underway to relate the structure of hypusine to the function of eIF-4D and to understand the posttranslational control of hypusine biosynthesis.
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会议论文
ESSENTIAL CELLULAR FUNCTION OF HYPUSINE IN ELF 5A
HYPUSINE IN EIF-4D--BIOSYNTHESIS AND FUNCTION
ESSENTIAL CELLULAR FUNCTION OF HYPUSINE IN ELF 5A
HYPUSINE IN EIF-4D--BIOSYNTHESIS AND FUNCTION
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