THEORETICAL STUDIES ON THE DYNAMIC ASPECTS OF MACROMOLECULAR FUNCTION

气相简正波分析，已被用来研究 集体运动的频率和幅度 大分子，已被推广到液体中， 摩擦力起着重要作用。在…的框架内 朗之万方程，这个问题已经归结为解一个 由超矩阵构造的特征值方程 力常数和摩擦力矩阵及计算 获得了相关的便捷表达式 实验上可获得的相关函数。初步 计算表明，这种方法提供了一种可行的方法。 测定溶剂对反应动力学的影响 大分子中的集体运动。瞬变电学 DNA等聚电解质的双折射(TEB)不反映 不仅是大离子的自转运动，而且还有动力学 周围的离子大气。通过正确对待 旋转动力学和反离子动力学之间的耦合，严格 外加电场转动时TEB的表达式 获得了导通、反转或振荡，并成功地用于 对近期短DNA限制实验数据的分析 碎片。微电极的电流理论 带状和环状几何已被开发并应用于 使用这种装置进行电化学测量的分析。

Gas-phase normal mode analyses, that have been used to study the frequencies and amplitudes of collective motions in macromolecules, have been generalized to the liquid phase where frictional forces play a important role. Within the framework of the Langevin equation, the problem has been reduced to solving an eigenvalue equation involving supermatrix constructed from the force constant and friction matrices and computationally convenient expressions have been obtained for the relevant experimentally accessible correlation functions. Preliminary calculations indicate that this approach provides a viable means of determining the influence of solvent on the dynamics of collective motions in macromolecules. The transient electric birefringence (TEB) of polyelectrolytes such as DNA, reflects not only the rotational motion of the macroions but also the dynamics of the surrounding ion atmosphere. By correctly treating the coupling between the rotational and counterion dynamics, rigorous expressions for the TEB when an external electric fields is turned on, reversed or oscillates were obtained and used to successfully analyze recent experimental data on short DNA restriction fragments. The theory of the current to microelectrodes with band and ring geometries has been developed and applied to the analysis of electrochemical measurements using such devices.