PSYCHOPHYSIOLOGICAL EFFECTS OF STIMULANT DRUGS IN CHILDREN

急性和慢性给药的效果试验 咖啡因对自主神经系统(ANS)的作用 已经开展了评估ANS活动在 这种药物的行为和主观影响。对…的测试 使用反应时间方法的注意力也包括在内。 测试协议涉及记录ANS的外围指示器 活动，如皮肤电导(SC)、心率(HR)和皮肤 在由休息期组成的会话期间的温度， 呈现一系列没有反应的简单音调 必填项，以及反应时间任务。已经进行了研究 关于两种剂量的急性给药的效果 6-13岁男孩和男性中的咖啡因和安慰剂，以及 儿童慢性(2周)咖啡因摄入量的研究。 急性和长期使用咖啡因的效果 唤醒的SC指数增加了，但有一些趋势是 人力资源的减少。SC的结果与 咖啡因可以被认为是一种药理学的假说 焦虑模型，但人力资源效应表明该模型是 不完美。 最近的一项研究，咖啡因的急性剂量方案是 对患有焦虑症的儿童和对照组进行了调查。这 验证了这一假设，这一假设在成年人中有证据表明 焦虑症患者对咖啡因更敏感 而不是控制。 另一项目前的研究比较了自闭症患者的活动和注意力 被诊断为品行障碍和注意力缺陷的男孩 无序。

Tests of the effects of acute and chronic administration of caffeine on autonomic nervous system (ANS) functioning have been carried out to evaluate the role of ANS activity in the behavioral and subjective effects of this drug. A test of attention using a reaction time method is included. The test protocol involves recording peripheral indicators of ANS activity such as skin conductance (SC), heart rate (HR), and skin temperature during a session consisting of a rest period, presentation of a series of simple tones to which no response is required, and the reaction time task. Studies have been carried out on the effects of the acute administration of two doses of caffeine and a placebo in 6-13 year old boys and in men, and a study of chronic (2 week) caffeine intake in children. The effects of both acute and chronic administration of caffeine were increases in SC indices of arousal but some trends toward decreases in HR. The SC results are consistent with the hypothesis that caffeine can be considered a pharmacologic model for anxiety, but the HR effects suggest the model is imperfect. The most recent study, an acute dose protocol with caffeine was conducted on children with anxiety disorders and controls. This tested the hypothesis, for which there is evidence in adults, that patients with anxiety disorders are more sensitive to caffeine than controls. Another current study compares ANS activity and attention in boys with diagnoses of Conduct Disorder and Attention Deficit Disorder.