CORTICOSTRIATAL NEURONS IN MOTOR CORTEX OF PRIMATES DURING WRIST MOVEMENT

尽管众所周知，对地层的主要投入 起源于大脑皮层，几乎对此一无所知 皮质纹状体通路所传递的信息类型。 纹状体的一部分，接受来自初级大脑的输入 运动皮质是壳核。壳核神经元在或 发作后的肌电活动和反映的方向 运动本身，而初级运动中的许多神经元 皮层放电开始前的肌电活动和反射 独立于方向的个体肌肉活动 有动静。研究大脑皮质纹状体(CS)的活动 运动，我们开发了一种策略来识别CS神经元和 量化它们的活动，它们相对于运动的时间， 以及它们与肌肉激活模式的关系。 恒河猴。我们的观察表明，马达 信息是通过神经元传递的，而不是通过壳核神经元 尊重它们的时机和与肌肉模式的关系 活动。因此，运动障碍有可能 由于CS活动过多而导致异常 肌肉的收缩和肢体在空间中的位置。

Although it is well known that the major input to the stratium originates in the cerebral cortex, virtually nothing is known about the type of information conveyed by the corticostriatal pathway. The part of the striatum that receives input from the primary motor cortex is the putamen. Putamen neurons discharge at or after the onset of EMG activity and reflect the direction of movement per se, whereas many neurons in the primary motor cortex discharge prior to the onset of EMG activity and reflect individual muscle activity independent of the direction of movement. To investigate corticostriatal (CS) activity during movement, we developed a strategy to identify CS neurons and quantitate their activity, their timing with respect to movement, and their relationship to the pattern of muscle activation in rhesus monkeys. Our observations indicate that motor information is conveyed via neurons than putamen neurons with respect to their timing and relationship to the patterns of muscle activity. It is possible, therefore, that motor disorders could result from excess in CS activity that causes abnormal contraction of muscles and limb position in space.