母亲患有抑郁症的健康儿童的身体/神经发育-猫眼课题宝

母亲患有抑郁症的健康儿童的身体/神经发育

批准号：

3944794

负责人：

T SHERMAN

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE OF MENTAL HEALTH

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3944794

关键词：

behavioral genetics child mental disorders child physical development child psychology human subject mental disorder diagnosis nervous system disorder diagnosis neurologic manifestations parent offspring interaction sign /symptom

中文摘要

翻译

令人兴奋的当前工作的生化和遗传基础，主要的情感障碍使得更加突出的需要，架起科学的桥梁，并开始发展概念和标记将身体和神经基质与复杂的这些疾病的行为表现。一个发展框架为超越相关性提供了基础评估因果模型。该项目将是这方面的一个步骤过程关于儿童出生并发症的丰富数据，发展、认知发展和神经系统发展将汇集在一起，作为个人的概况，孩子将对这些概况进行聚类分析。它预计一些儿童群体将被与情感性疾病的高家庭负担有关。是还预计，特定的集群将与具体的社会，情感和/或认知结果，或与情感疾病症状的发展，和/或行为儿童的疾病。

英文摘要

The exciting current work on the biochemical and genetic bases of the major affective disorders makes more salient the need to bridge the sciences and begin to develop concepts and markers linking the physical and neurological substrate with the complex behavioral manifestations of these disorders. A developmental framework provides a basis for moving beyond correlational assessment to causal modeling. The project will be a step in this process. A rich body of data on the children's birth complications, physical development, cognitive development and neurological development will be brought together as profiles for individual children. These profiles will be subjected to a cluster analysis. It is expected that some of the clusters of children will be associated with higher family loadings for affective illness. It is also expected that particular clusters will be associated with specific social, emotional, and/or cognitive outcomes, or with the development of symptoms of affective illness, and/or behavioral disorders in the children.

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