CENTER FOR CLINICAL RESEARCH IN EPILEPSY

该临床中心补助金提案的中心主题是临床 癫痫现象。 这是一个庞大而复杂的提案， 指出由一个由29个独立提案组成的相互交织的提案， 大型和广泛的多学科临床科学家群体。 因此 拟议的研究包括对几种具体形式的 成人和儿童的药物治疗，包括评估和 抗惊厥新药的临床试验 一系列详细的 建议进行药代动力学研究， 药物的生物学后果，包括怀孕期间的变化。 临床神经生理学的研究包括试图发展脑电图 癫痫发作频率的预测因素， 电生理放电、行为激活脑电图改善 诊断分辨率以及语言定位的EEG研究， 在外科治疗的判断中会产生重要的影响。 提高诊断能力的放射学技术包括使用 CT扫描来解决定位的模糊性， 有助于切迹硬化的诊断。 癫痫发作频率 提出了各种有趣的统计问题和计算机建模 癫痫发作频率将被检查以及其他统计研究 在癫痫中。 这些延伸到流行病学的几个领域研究， 现象以及特定环境因素的作用，如 压力和抑郁作为癫痫发作频率的决定因素。 等 神经心理学研究延伸到康复领域 将对最佳技术进行对照研究， 评估就业安置能力和成本效益 具体的康复措施以及消费者的参与。 最后，研究确定各种教育的有效性， 涉及公众和医疗专业的技术是 建议包括在疗养院和癫痫的教育工作 这条信息线将有望揭示那些最高的问题， 癫痫病人优先。 因此，有一个广泛的 从生物学研究到社会心理学领域的项目。

The central theme of this Clinical Center Grant proposal is the clinical phenomenon of Epilepsy. It is a large, complex proposal designed to indicate the interdigitations of 29 individual proposals generated by a large and broad group of multidisciplinary clinical scientists. Thus, the proposed studies include evaluations of several specific forms of pharmacological therapy in adults and children including the evaluation and clinical trial of new anticonvulsant drugs. A series of detailed pharmacokinetic studies are proposed as well as examination of several biological consequences of drugs including changes during pregnancy. Studies in clinical neurophysiology include an attempt to develop EEG predictors of seizure frequency, computer analysis of various elements of the electrophysiological discharge, behavioral activation of EEG to improve diagnostic resolution as well as EEG studies of language localization which can have important consequences in theraputic surgical judgements. Radiologic techniques to improve diagnostic capabilities include the use of the CT scan to resolve ambiguities regarding localization and hopefully to assist in the diagnosis of incisural sclerosis. Frequency of seizures raises a variety of interesting statistical questions and computer modeling of seizure frequency will be examined as well as other statistical studies in epilepsy. These extend into several field studies of epidemiological phenomena as well as the roles of specific enviornmental factors such as stress and depression as determinates of seizure frequency. Such neuropsychological investigations extend into the area of rehabilitation where controlled studies will be undertaken of optimal techniques for evaluating capabilities for job placement and the cost effectiveness of specified rehabilitation measures as well as consumer involvement. Finally, studies to determine the effectiveness of various educational techniques involving both the public as well as the medical profession are proposed including educational efforts in nursing homes and an epilepsy information line which will hopefully uncover those problems of highest priority to patients with epilepsy. Thus, there is a broad spectrum of projects ranging from biological studies to those in the psychosocial area.