Next Generation Sequencing High Throughput Epigenomics

最近的证据表明，一个成年人？她们的健康状况和对常见疾病的易感性有时可以追溯到她们的母亲或祖母在怀孕期间所经历的环境和营养影响。经历?胎儿在母亲体内发育的情况？S子宫似乎改变了个体基因组在以后生活中的解释方式，在某些情况下，导致对某些疾病的易感性增加。在某些情况下，即使在没有原始条件的情况下，这种改变的基因组解释也可以传递给下一代。虽然我们有整个人类基因组的序列，但我们对它是如何工作的，以及它是如何被细胞解释的知之甚少。在这个项目中，我们将利用DNA测序技术的最新突破，这将使我们能够从细胞发育之前、期间和之后的基因组中收集大量的数据。除了揭示基因组运作的重要信息外，这些结果将为成人疾病的胎儿起源提供重要见解，并可能导致新的预防策略和新的药物或治疗方法来治疗影响生活质量的疾病。

Recent evidence suggests that an adult individual?s health and susceptibility to common diseases can sometimes be traced back to environmental and nutritional effects experienced by their mothers or grandmothers during pregnancy. The ?experiences? of the foetus during development in its mother?s womb appears to alter the way that an individuals genome is interpreted in later life leading to, in some cases, increase susceptibility to certain diseases. This altered genome interpretation can in some cases be passed passed on to the next generation as well, even in the absence of the original conditions. Though we have the sequence of the entire human genome, we know little about how it works, and how it is interpreted by cells. In this project we will take advantage of recent breakthroughs in DNA sequencing technologies that will permit us to collect hugely increased amounts of data from the genomes of cells before, during and after development. In addition to revealing important information about the workings of the genome these results will provide important insights into the fetal origins of adult disease and potentially lead to new strategies for prevention and new medicines or therapies for treatment of conditions that affect the quality of life.